2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties

Melting point:

158°C

Boiling point:

255.2±40.0 °C(Predicted)

Density 

1.61±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

5.71±0.10(Predicted)

form 

solid

color 

Yellow

InChI

InChI=1S/C6H3F3N2O3/c7-6(8,9)4-1-3(11(13)14)2-10-5(4)12/h1-2H,(H,10,12)

InChIKey

BHUILUYFGJBXHQ-UHFFFAOYSA-N

SMILES

C1(=O)NC=C([N+]([O-])=O)C=C1C(F)(F)F

LogP

0.41 at 25℃

CAS DataBase Reference

99368-66-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2933399990

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Usage And Synthesis

Chemical Properties

2-Hydroxy-5-nitro-3-trifluoromethylpyridine is solid at room temperature and pressure, and it is a pyridine derivative. The hydroxyl group in the 2nd position in the structure and the double bond on the pyridine ring form the enol form that will be reciprocally isomorphic into the structure of amide.

Uses

2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine is a class of aromatic heterocyclic compounds that can be used as intermediates for Apalutamide, which is an androgen receptor inhibitor used in the treatment of prostate cancer.

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE(99368-66-8)Related Product Information

• 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE
• 3-BroMo-6-chloropyridin-2-ol
• 2-HYDROXY-5-METHYLPYRAZINE
• 6-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE
• 2-HYDROXY-5-IODO-BENZONITRILE
• 3-Cyano-2-hydroxy-5-iodopyridine
• 2-BROMO-5-NITRO-6-PICOLINE
• 3-Amino-5-fluoropyridine
• 2-Cyano-5-fluoropyridine
• 2-METHOXY-5-NITRO-6-PICOLINE
• 2-Pyridinecarboxylic acid, 3-fluoro-4-iodo-
• 3-FLUOROPYRIDINE-2-CARBOXYLIC ACID
• 4-Methoxy-3-nitropyridine
• 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
• 2-Hydroxy-3-trifluoromethylpyridine
• 2-HYDROXY-3-METHYL-5-NITROPYRIDINE
• 3-METHYL-5-NITROPYRIDINE
• 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE