2-Fluoropyridine Chemical Properties

Boiling point:

126 °C/753 mmHg (lit.)

Density 

1.128 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.466(lit.)

Flash point:

83 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

pka

-0.44(at 25℃)

color 

Clear colorless to light yellow

Specific Gravity

1.13

Water Solubility 

Soluble in water.

BRN 

1515

Dielectric constant

37.289999999999999

InChI

InChI=1S/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H

InChIKey

MTAODLNXWYIKSO-UHFFFAOYSA-N

SMILES

C1(F)=NC=CC=C1

CAS DataBase Reference

372-48-5(CAS DataBase Reference)

NIST Chemistry Reference

2-Fluoropyridine(372-48-5)

Safety Information

Hazard Codes 

Xi,F,Xn

Risk Statements 

10-36/37/38-20/21/22

Safety Statements 

26-36-36/37/39-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

UT3900000

Hazard Note 

Flammable/Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29333999

MSDS

• Language:English Provider:2-Fluoropyridine
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• Language:English Provider:SigmaAldrich
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2-Fluoropyridine Usage And Synthesis

Synthesis

A rare example of fluorodenitration of a heterocyclic system was provided by 2- nitropyridine, which was converted to 2-fluoropyridine.

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.

2-Fluoropyridine(372-48-5)Related Product Information

• 2-(Trifluoromethyl)benzoic acid
• 2-Fluorobenzoyl chloride
• 1-Fluoro-2-nitrobenzene
• 2-Methylbenzotrifluoride
• 2-Fluoroaniline
• Flupirtine
• 2-(Trifluoromethyl)benzyl chloride
• Chromium picolinate
• 2,6-Lutidine
• Methyl propyl carbonate
• 2-Bromofluorobenzene
• 2-Chloro-3-cyanopyridine
• alpha-Chloro-o-fluorotoluene
• Sulfasalazine
• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• 4-Amino-2-fluoropyridine
• 2-Fluoropyridine-4-boronic acid
• 3-Chloro-2,4,5,6-tetrafluoropyridine