Basic information Safety Supplier Related

Palmitoyl-L-Carnitine Chloride

Basic information Safety Supplier Related

Palmitoyl-L-Carnitine Chloride Basic information

Product Name:
Palmitoyl-L-Carnitine Chloride
Synonyms:
  • O-PALMITOYL-L-CARNITINE CHLORIDE
  • PALMITOYL-L-CARNITINE CHLORIDE
  • Palmitoyl-L-carnitine hydrochloride
  • (R)-[3-carboxy-2-[(1-oxohexadecyl)oxy]propyl]trimethylammonium chloride
  • HEXADECANOYL-L-CARNITINE CHLORIDE
  • 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(1-oxohexadecyl)oxy-, chloride, (2R)-
  • L-Palmitoylcarnitine chloride
  • 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-((1-oxohexadecyl)oxy)-, chloride, (R)-
CAS:
18877-64-0
MF:
C23H46ClNO4
MW:
436.07
EINECS:
242-642-6
Mol File:
18877-64-0.mol
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Palmitoyl-L-Carnitine Chloride Chemical Properties

Melting point:
168-172 °C(lit.)
storage temp. 
-20°C
solubility 
H2O: 25 mg/mL with heat or sonication
form 
powder
color 
white
BRN 
4071005
CAS DataBase Reference
18877-64-0
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
3-10

MSDS

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Palmitoyl-L-Carnitine Chloride Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

Palmitoyl-L-carnitine Hydrochloride is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ?-oxidation defects.

Uses

Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).

Biochem/physiol Actions

Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.

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