PLX3397 HCl
PLX3397 HCl Basic information
- Product Name:
- PLX3397 HCl
- Synonyms:
-
- PLX3397 HCl
- Pexidartinib hcl
- Pexidartinib hydrochloride (PLX-3397)
- Pexidartinib Hydrochloride Salt
- Pexidartinib hydrochloride, PLX-3397 HCl
- PLX-3397 hydrochloride
- Pexidartinib hydrochloride (PLX-3397 hydrochloride)
- 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine hydrochloride
- CAS:
- 2040295-03-0
- MF:
- C20H16Cl2F3N5
- MW:
- 454.28
- Product Categories:
-
- API
- Mol File:
- 2040295-03-0.mol
PLX3397 HCl Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:60.0(Max Conc. mg/mL);132.1(Max Conc. mM)
- form
- Solid
- color
- White to off-white
- InChIKey
- CJLUYLRKLUYCEK-UHFFFAOYSA-N
- SMILES
- C(C1=CN=C(NCC2=CN=C(C(F)(F)F)C=C2)C=C1)C1=CNC2=NC=C(Cl)C=C12.Cl
PLX3397 HCl Usage And Synthesis
Uses
Pexidartinib Hydrochloride is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.
in vivo
Pexidartinib can be used to deplete the microglia cells in mice.
Pexidartinib (290 ppm in AIN-76A standard chow, 21 days) depletes the microglia cells in brain by 70% in adult male C57BL/6?J mice (20–25?g)[5].
Pexidartinib (600 ppm in chow, 10 days and 30 days ) depletes the microglia cells more than 90% in brain of C57BL/6J mice[6].
Pexidartinib hydrochloride (0.25, 1 mg/kg, i.p., twice daily for 8 days) inhibits the proliferation of microglia and BrdU-positive cells in neonatal mice[2].
Pexidartinib hydrochloride (1 mg/kg, twice daily for 8 day) shows no obvious effect on the cleaved caspase-3-positive cells in mice[2].
Pexidartinib hydrochloride (50 mg/kg; p.o.; every second day for 3 weeks) reduces tissue macrophage levels without affecting glucose homeostasis in mice[4].
| Animal Model: | Neonatal mice[2] |
| Dosage: | 0.25, 1 mg/kg |
| Administration: | I.P. twice daily for 8 days |
| Result: | Decreased the number of microglia and BrdU-positive proliferative cells, but did not change the cleaved caspase-3-positive cells. |
| Animal Model: | 10-week old litter mate C57BL/6 mice (chow and high-fat diet fed mice)[4] |
| Dosage: | 50?mg/kg |
| Administration: | P.o.; every second day for 3 weeks |
| Result: | Substantially reduced macrophage numbers in adipose tissue of both chow and high-fat diet fed mice without affecting total myeloid cell levels. |
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