Basic information Safety Supplier Related

PF-6274484

Basic information Safety Supplier Related

PF-6274484 Basic information

Product Name:
PF-6274484
Synonyms:
  • PF-6274484
  • N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
  • 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-
  • PF-6274484 >=98% (HPLC)
  • oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor
  • N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide
CAS:
1035638-91-5
MF:
C18H14ClFN4O2
MW:
372.78
Mol File:
1035638-91-5.mol
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PF-6274484 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 33 mg/ml; DMSO: 25 mg/ml
form 
A crystalline solid
color 
Light yellow to orange
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PF-6274484 Usage And Synthesis

Description

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.

PF-6274484Supplier

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Email
klq@cw-bio.com
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
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PF-6274484(1035638-91-5)Related Product Information