JNJ-10229570
JNJ-10229570 Basic information
- Product Name:
- JNJ-10229570
- Synonyms:
-
- JNJ-10229570
- JNJ-10229570; JNJ10229570; JNJ 10229570
- UNII-N9IX402L35
- Benzenamine, N-[2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]-
- JNJ-10229571
- 2,3-Bis(2-methoxyphenyl)-N-phenyl-1,2,4-thiadiazol-5(2H)-imine
- JNJ-10229570,MC Receptor,Inhibitor,inhibit,Melanocortin Receptor
- N-[2,3-Bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]aniline
- CAS:
- 524923-88-4
- MF:
- C22H19N3O2S
- MW:
- 389.47
- Mol File:
- 524923-88-4.mol
JNJ-10229570 Chemical Properties
- Boiling point:
- 541.2±60.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 62.5 mg/mL (160.47 mM)
- form
- Solid
- pka
- 0.95±0.20(Predicted)
- color
- Light yellow to yellow
JNJ-10229570 Usage And Synthesis
Uses
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
in vivo
Topical treatment with JNJ-10229570 of human skins transplanted onto SCID mice result in a marked decrease in sebum-specific lipid production, sebaceous gland's size and the expression of the sebaceous differentiation marker epithelial-membrane antigen (EMA). Topical treatment with 0.05% JNJ-10229570 leads to a distinct reduction in both the steady-state and the newly-synthesized sebum-specific lipids, with lesser effects on triglycerides and cholesterol[1].
References
[1] Eisinger M, et al. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. DOI:10.1016/j.jdermsci.2011.04.001
JNJ-10229570Supplier
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- 021-61312847; 18021002903
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