Roxatidine
Roxatidine Basic information
- Product Name:
- Roxatidine
- Synonyms:
-
- ROXATIDINE
- n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide
- 2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide
- 2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide
- ROXATIDINE ENTERPRISE STANDARD
- RoxatidineAcetateHclBase
- ROXATIDINE(SUBJECTTOPATENTFREE)
- desacetyl-TZU-0460
- CAS:
- 78273-80-0
- MF:
- C17H26N2O3
- MW:
- 306.4
- Product Categories:
-
- APIs
- Mol File:
- 78273-80-0.mol
Roxatidine Chemical Properties
- Melting point:
- 59-60 °C
- Boiling point:
- 524.3±45.0 °C(Predicted)
- Density
- 1.137±0.06 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- pka
- 13.34±0.10(Predicted)
- form
- oil
- color
- Colorless to pale yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 78273-80-0(CAS DataBase Reference)
Roxatidine Usage And Synthesis
Description
Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
Uses
Anti-ulcerative.
in vivo
Roxatidine (20 mg/kg, p.o., a single dose for 1h before Compound 48/80 injection) ameliorates Compound 48/80 (HY-115768) (8mg/kg, i.p., a single dose for 1h)-induced allergic hypersensitivity and suppresses Compound 48/80-induced allergic inflammation in anaphylactic animal model[1].
| Animal Model: | Compound 48/80-induced anaphylactic shock mouse model[1] |
| Dosage: | 20 mg/kg |
| Administration: | p.o., a single dose for 1h before Compound 48/80 injection |
| Result: | Increased the survival rate to 20% at 60 min after compound 48/80 injection. |
IC 50
H2 Receptor
References
[1] J G MILLS J R W. The pharmacology of histamine H2-receptor antagonists.[J]. Methods and findings in experimental and clinical pharmacology, 1989, 11 Suppl 1: 87-95.
[2] EU-JIN CHO. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages†[J]. Journal of cellular biochemistry, 2011, 112 12: 3648-3659. DOI:10.1002/jcb.23294
[3] HIROYUKI IMAEDA. Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia.[J]. Journal of Gastroenterology, 2011, 46 11: 1267-1272. DOI:10.1007/s00535-011-0447-1
[4] RENHAO ZE. Roxatidine Attenuates Degradation of Extracellular Matrix.[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017: 1156-1160. DOI:10.1016/j.biopha.2017.08.130
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Roxatidine(78273-80-0)Related Product Information
- Acetamide
- Famotidine
- Propyl butyrate
- Thioacetamide
- 3-Mercaptopropyltriethoxysilane
- Cimetidine
- DIACETAMIDE
- Propyl gallate
- Acetaminophen
- 3-Chloropropyltriethoxysilane
- 3-Aminopropyltriethoxysilane
- N,N-Dimethylacetamide
- 3-(1-Piperidinylmethyl)phenol
- ROXATIDINE OXALATE
- ROXATIDINE ACETATE
- ROXATIDINE ACETATE HYDROCHLORIDE,ROXATIDINE ACETATE HCL,ROXATIDINE HCL ACETATE
- N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]amine
- 2-HYDROXYACETAMIDE