6-HYDROXY-7-METHOXYCOUMARIN Chemical Properties

Melting point:

206-208°C

Boiling point:

413.5±45.0 °C(Predicted)

Density 

1.37 g/cm3

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: soluble

pka

8.94±0.20(Predicted)

form 

Solid

color 

Pale Beige to Light Beige

LogP

0.830 (est)

CAS DataBase Reference

776-86-3

Safety Information

Hazard Codes 

Xi

Risk Statements 

22-36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

F 

8

HS Code 

29322090

MSDS

• Language:English Provider:SigmaAldrich

6-HYDROXY-7-METHOXYCOUMARIN Usage And Synthesis

Description

Isoscopolamine is an antiasthmatic drug, which has the effect of relaxing smooth muscle and antihistamine. It can be used clinically in patients with chronic bronchitis and bronchial asthma.

Chemical Properties

Yellow needle-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dengzhanhua, Rhododendron.

Uses

Isoscopolamine has anti-inflammatory, antioxidant, improving myocardial ischemia, anti-arrhythmic effects.

Definition

ChEBI: Isoscopoletin is a hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. It has a role as a plant metabolite. It is a hydroxycoumarin and an aromatic ether. It is functionally related to an esculetin.

Biological Activity

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in Artemisia argyi. It has a significant inhibitory effect on cell proliferation with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and drug-resistant subline CEM/ADR5000, respectively. It (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication.

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