Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Catalyst and Auxiliary >  polymer >  POMALIDOMIDE-PEG1-CO2H

POMALIDOMIDE-PEG1-CO2H

Basic information Safety Supplier Related

POMALIDOMIDE-PEG1-CO2H Basic information

Product Name:
POMALIDOMIDE-PEG1-CO2H
Synonyms:
  • POMALIDOMIDE-PEG1-CO2H
  • Pomalidomide-PEG1-CO2H >=95%
  • Pomalidomide-PEG1-COOH
  • Pomalidomide-PEG1-C2-COOH
  • 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid
  • Thalidomide-4-NH-PEG1-COOH
  • Thalidomide-NH-PEG1-C2-COOH
  • Propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]-
CAS:
2139348-60-8
MF:
C18H19N3O7
MW:
389.36
Product Categories:
  • peg
Mol File:
2139348-60-8.mol
More
Less

POMALIDOMIDE-PEG1-CO2H Chemical Properties

Boiling point:
726.2±60.0 °C(Predicted)
Density 
1.508±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
powder or crystals
pka
4.29±0.10(Predicted)
More
Less

POMALIDOMIDE-PEG1-CO2H Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG1-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

storage

Store at -20°C

POMALIDOMIDE-PEG1-CO2HSupplier

Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Email
han_yajun@dctc.daicel.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Borenpharm Co., Ltd
Tel
027-65563561
Email
sales@borenpharm.com
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Email
info@SuperLan-chem.com