Basic information Description References Safety Supplier Related
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ETIZOLAM

Basic information Description References Safety Supplier Related

ETIZOLAM Basic information

Product Name:
ETIZOLAM
Synonyms:
  • 4-c)thieno(2,3-e)(1,4)-diazepine,6-(o-chlorophenyl)-8-ethyl-1-4h-s-triazolo(
  • 6-(o-chlorophenyl)-8-ethyl-1-methyl-4h-s-triazolo(3,4-c)thieno(2,3-e)(1,4)-d
  • 6-(o-chlorphenyl)-8-aethyl-1-methyl-4h-s-triazolo(3,4-c)thieno(2,3-e)(1,4)di
  • 6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine,4-(2-chlorophenyl)-2-et
  • 8-ethyl-6-(o-chlorophenyl)-1-methyl-4h-s-triazolo(3,4c)thieno(2,3e)-1,4-diaz
  • ahr3219
  • azepin
  • depas
CAS:
40054-69-1
MF:
C17H15ClN4S
MW:
342.85
EINECS:
662-368-4
Product Categories:
  • pharmaceutical intermediate and medicine grade
  • pharmaceutical intermediate
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • intermediate
Mol File:
40054-69-1.mol
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ETIZOLAM Chemical Properties

Melting point:
147-148℃
Boiling point:
264.5°C (rough estimate)
Density 
1.43
refractive index 
1.6100 (estimate)
Flash point:
9°C
storage temp. 
-20°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form 
A neat solid
pka
2.37±0.40(Predicted)
CAS DataBase Reference
40054-69-1
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Toxicity
LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari)
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ETIZOLAM Usage And Synthesis

Description

Etizolam is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety or panic attacks. It has amnesic, anxiolytic, anticonvulsant, and hypnotic, sedative and skeletal muscle relaxant properties. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system.

References

https://www.drugbank.ca/drugs/DB09166
https://en.wikipedia.org/wiki/Etizolam
Casacchia, Massimo, F. Bolino, and U. Ecari. "Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo."Current Medical Research & Opinion 12.4(2008):215-223.
Savoldi, F, G. Somenzini, and U. Ecari. "Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study."Current Medical Research & Opinion 12.3(1990):185.
Hirashima, Y, et al. "Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography." Neurologia medico-chirurgica 42.2(2002):53-55.

Description

Etizolam is a potent thienodiazepine anxiolytic closely related to brotizolam. Pharmacologically, however, its profile most resembles that of diazepam.

Originator

Yoshitomi (Japan)

Uses

Etilozam is a a thienodiazepine benzodiazepine derivative, and has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic related to that of the classic benzodiazepines. Etizolam has effect on monoamine metabolism in brain. Etilozam can be used for the short-term treatment of insomnia, anxiety or panic attacks.

Uses

Nasal Dilator

Definition

ChEBI: Etizolam is an organic molecular entity.

brand name

DEPAS

ETIZOLAMSupplier