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Voriconazole (2R,3R)-Isomer

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Voriconazole (2R,3R)-Isomer Basic information

Product Name:
Voriconazole (2R,3R)-Isomer
Synonyms:
  • Voriconazole (2R,3R)-Isomer
  • (2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1- (1H-1,2,4-triazol-1-yl)butan-2-ol (1:1)
  • (αR,βR)-rel-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • 4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-rel-
  • Voriconazole 3-Epimer
  • (αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol
  • (2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S)
  • Azilsartan medoxomil impurity317
CAS:
137234-76-5
MF:
C16H13ClF3N5O
MW:
383.76
Mol File:
137234-76-5.mol
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Voriconazole (2R,3R)-Isomer Chemical Properties

Boiling point:
529.9±60.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Dichloromethane (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol
pka
11.44±0.29(Predicted)
form 
Solid
color 
White to Off-White
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Voriconazole (2R,3R)-Isomer Usage And Synthesis

Uses

(αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol is an intermediate in synthesizing rel-(R,R)-Voriconazole (V759990), The (R,R)-enantiomer of Voriconazole. An antifungal (systemic). An ergosterol biosynthesis inhibitor.

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