Ryanodine Chemical Properties

alpha 

D25 +26° (methanol)

Boiling point:

586.95°C (rough estimate)

Density 

1.2805 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: soluble10mg/mL, clear

form 

White solid

Melting point:

219-220 °C

pka

10.66±0.70(Predicted)

color 

white to beige

CAS DataBase Reference

15662-33-6

EPA Substance Registry System

Ryanodine (15662-33-6)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

21/22-50/53

Safety Statements 

36/37-60-61

RIDADR 

UN 3077 9/PG 3

RTECS 

VM4025000

Ryanodine Usage And Synthesis

Description

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemical Properties

white to off-white solid

Uses

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Uses

Insecticide.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biological Activity

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

storage

-20°C (desiccate)

References

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

Ryanodine(15662-33-6)Related Product Information

• CYCLODODECYL FORMATE
• CYCLODODECANE
• CYCLOOCTANEMETHANOL
• 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
• Ryanodine
• 1,4-Cyclohexanedimethanol
• trans-1,2-Cyclopentanediol
• CYCLODODECYLMETHYL ETHER
• CYCLOOCTANOL
• CIS-1,2-CYCLOOCTANEDIOL
• (1S)-TRANS-1,2-CYCLOPENTANEDIOL
• (1R)-TRANS-1,2-CYCLOPENTANEDIOL MONOACETATE
• (3S,5S)-2,6-Dimethyl-3,5-heptanediol
• (R,R)-(-)-1,2-CYCLODODECANEDIOL
• (-)-NEOMENTHOL
• CIS-P-MENTHANE-3,8-DIOL
• 3-Deoxyryanodol
• (S,S)-(+)-1,2-CYCLODODECANEDIOL