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Ryanodine

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Ryanodine Basic information

Product Name:
Ryanodine
Synonyms:
  • Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem
  • Ryanex
  • Ryanexcel
  • Ryanodine,99%
  • 6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania
  • Ryanodine from Ryania speciosa
  • Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa
  • RYANODINE MIXTURE
CAS:
15662-33-6
MF:
C25H35NO9
MW:
493.55
EINECS:
239-732-2
Product Categories:
  • Signalling
  • Alkaloids
  • InsP3/Ryanodine receptor
Mol File:
15662-33-6.mol
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Ryanodine Chemical Properties

alpha 
D25 +26° (methanol)
Boiling point:
586.95°C (rough estimate)
Density 
1.2805 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
White solid
Melting point:
219-220 °C
pka
10.66±0.70(Predicted)
color 
white to beige
CAS DataBase Reference
15662-33-6
EPA Substance Registry System
Ryanodine (15662-33-6)
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
21/22-50/53
Safety Statements 
36/37-60-61
RIDADR 
UN 3077 9/PG 3
RTECS 
VM4025000
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Ryanodine Usage And Synthesis

Description

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemical Properties

white to off-white solid

Uses

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Uses

Insecticide.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biological Activity

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

storage

-20°C (desiccate)

References

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

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