Pomalidomide-PEG5-CO2H Chemical Properties

Boiling point:

791.0±60.0 °C(Predicted)

Density 

1.360±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

4.28±0.10(Predicted)

form 

Solid-Liquid Mixture

color 

White to yellow

Pomalidomide-PEG5-CO2H Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG₅-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: amine reactive
reagent type: ligand-linker conjugate

IC 50

Cereblon

storage

Store at -20°C

Pomalidomide-PEG5-CO2H(2139348-63-1)Related Product Information

• Pomalidomide-PEG3-CO2H
• E3 Ligase Ligand-Linker Conjugates 1
• POMALIDOMIDE-PEG2-CO2H
• Pomalidomide-PEG1-azide
• Pomalidomide-O-C4-NH2
• Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
• Pomalidomide-PEG3-N3
• Pomalidomide-PEG6-butyl iodide
• POMALIDOMIDE-PEG1-CO2H
• Pomalidomide-PEG3-Amine HCl salt
• Pomalidomide-PEG4-CO2H
• 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• E3 Ligase Ligand-Linker Conjugates 22
• Pomalidomide-PEG2-butyl iodide
• Pomalidomide-PEG4-azide
• Pomalidomide-PEG2-N3
• E3 ligase Ligand-Linker Conjugates 50
• POMALIDOMIDE-PEG1-ALKYNE