Avibactam Impurity 46
Avibactam Impurity 46 Basic information
- Product Name:
- Avibactam Impurity 46
- Synonyms:
-
- Avibactam Impurity 46
- sodium (2R,5R)-2-cyano-7-oxo-6-azabicyclo[3.2.1]octan-6-yl sulfate
- WCK4234
- Sulfuric acid, mono[(1R,2S,5R)-2-cyano-7-oxo- 1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1)
- inhibit,carbapenemases,antibacterial,KPC enzymes,diazabicyclooctanes (DBOs),Enterobacteriaceae,Bacterial,Inhibitor
- Avibactam Impurity 67 Sodium Salt
- CAS:
- 1804915-68-1
- MF:
- C7H10N3NaO5S
- MW:
- 271.22
- Mol File:
- 1804915-68-1.mol
Avibactam Impurity 46 Chemical Properties
- storage temp.
- -20°C, away from moisture
Avibactam Impurity 46 Usage And Synthesis
Biological Activity
WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2].
References
[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01666-19. [2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695.
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