4-Chloro-3-fluorophenol Chemical Properties

Melting point:

54-56 °C (lit.)

Boiling point:

84 °C/44 mmHg (lit.)

Density 

1.3675 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

chloroform: soluble50mg/mL, clear, colorless

pka

8.52±0.18(Predicted)

form 

Liquid

color 

Colorless to pale yellow, may discolor to orange during storage

BRN 

3236440

InChI

InChI=1S/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H

InChIKey

XLHYAEBESNFTCA-UHFFFAOYSA-N

SMILES

C1(O)=CC=C(Cl)C(F)=C1

CAS DataBase Reference

348-60-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36/37/39-24/25

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

IRRITANT, IRRITANT-HARMFUL

HazardClass 

8

HS Code 

29081990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Chloro-3-fluorophenol Usage And Synthesis

Chemical Properties

White to salmon crystalline solid

Uses

4-Chloro-3-fluorophenol was used in the synthesis of 4-chloro-3-fluoro catechol and 5-Chloro-4-fluoro-2-hydroxyacetophenone.

General Description

4-Chloro-3-fluorophenol is hydroxylated at both ortho positions to yield different products.

Synthesis

GENERAL METHOD: [2-(Phenoxy)-ethyl]-trimethyl-silane (195 mg, 1.0 mmol) was dissolved in anhydrous DMF (2 mL), cesium fluoride (576 mg, 3.0 mmol) was added, and the reaction was stirred for 1 hr at 60 °C. After the reaction was completed, the reaction mixture was diluted with water and extracted with ethyl acetate (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 92 mg of 4-chloro-3-fluorophenol in 93% yield. The 1H NMR data of the compound was consistent with the standard, confirming its structure.

References

[1] ISHIKAWA Y. 6-Chloro-7-fluoro-4-oxo-4H-chromene-3-carbaldehyde.[J]. Acta crystallographica. Section E, Structure reports online, 2014, 70 Pt 7: o825. DOI:10.1107/S1600536814014706.
[2] VIDYA S. SHIVATARE W. T. Vibronic and cation spectroscopy of selected rotamers of 4-chloro-3-fluorophenol[J]. Molecular Physics, 2014, 112 1: 2397-2406. DOI:10.1080/00268976.2014.904050.

4-Chloro-3-fluorophenol(348-60-7)Related Product Information

• 3-Chlorophenol
• 4-Chlorophenol
• Cyhalothrin
• 4-Fluorophenol
• λ-Cyhalothrin
• Difluorochloromethane
• 4-CHLORO-3-FLUOROANISOLE
• 2-CHLORO-6-FLUOROPHENOL,2-Chloro-6-fluorophenol, 97+%
• 2-BROMO-4-CHLORO-6-FLUOROPHENOL
• 2-CHLORO-3-FLUOROPHENOL
• 2-BROMO-6-CHLORO-4-FLUOROPHENOL
• 3-CHLORO-5-FLUOROPHENOL,3-Chloro-5-fluorophenol 98%,3-Chloro-5-fluorophenol98%
• Phenol, 4-amino-2-chloro-3-fluoro-
• 2-CHLORO-4-FLUOROPHENOL,2-Chloro-4-fluorophenol, 98+%,2-Chloro-4-fluorophenol99%,2-Chloro-4-fluorophenol 99%
• 2,3-DICHLORO-6-FLUOROPHENOL
• 2,6-DICHLORO-4-FLUOROPHENOL
• 3-Chloro-4-fluorophenol98%,3-Chloro-4-fluorophenol 98%,3-CHLORO-4-FLUOROPHENOL
• 3-CHLORO-2-FLUOROPHENOL