N-Caffeoyltryptophan Chemical Properties

Boiling point:

771.3±60.0 °C(Predicted)

Density 

1.460±0.06 g/cm3(Predicted)

pka

3?+-.0.10(Predicted)

form 

Solid

color 

White to off-white

N-Caffeoyltryptophan Usage And Synthesis

Uses

Caffeoyltryptophan is a competitive PTP1B inhibitor, with an IC50 of 16.99 μM. Caffeoyltryptophan can also inhibit α-glucosidase, linoleic acid peroxidation and haemolysis. Caffeoyltryptophan can be used for the research of type 2 diabetes[1].

Definition

ChEBI: N-Caffeoyltryptophan is a N-acyl-amino acid.

References

[1] Ha MT, et, al. PTP1B and α-glucosidase inhibitory activities of the chemical constituents from Hedera rhombea fruits: Kinetic analysis and molecular docking simulation. Phytochemistry. 2022 May:197:113100. DOI:10.1016/j.phytochem.2022.113100
[2] Ohnishi M, et, al. Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. Phytochemistry. 1998 Apr;47(7):1215-8. DOI:10.1016/s0031-9422(97)00754-1