MORPHOLIN-4-YL-ACETIC ACID Chemical Properties

Melting point:

162-164℃

Boiling point:

272℃

Density 

1.202

Flash point:

118℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

2.25±0.10(Predicted)

color 

Off-White

InChI

InChI=1S/C6H11NO3/c8-6(9)5-7-1-3-10-4-2-7/h1-5H2,(H,8,9)

InChIKey

VIWZVFVJPXTXPA-UHFFFAOYSA-N

SMILES

N1(CC(O)=O)CCOCC1

CAS DataBase Reference

3235-69-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

HazardClass 

IRRITANT

MORPHOLIN-4-YL-ACETIC ACID Usage And Synthesis

Uses

Morpholin-?4-?yl Acetic Acid was used in preparation of pyrrolidine-fused fullerene multicarboxylates by photoreaction.

Definition

ChEBI: N-(2-Carboxymethyl)-morpholine is an alpha-amino acid.

Synthesis

b) Synthesis of 2-morpholinoacetic acid Ethyl 2-morpholinoacetate (1 g, 57.8 mmol, 1.0 eq.) was dissolved in 8N HCl and the reaction was stirred at 95°C for 16 hours. Upon completion of the reaction, the reaction mixture was concentrated, quenched, and extracted as in Intermediate Example 15(b). The solvent was removed by distillation to afford the target product 2-morpholinoacetic acid in 96.3% (0.8 g) yield. The product was analyzed by LC-MS (ESI): calculated mass: 145.16; measured mass: 146.3 [M + H]+ (retention time: 0.21 min).

References

[1] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 40
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1489 - 1494
[3] Liebigs Annalen der Chemie, 1983, # 6, p. 950 - 961
[4] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0145
[5] Patent: WO2009/48559, 2009, A1. Location in patent: Page/Page column 70

MORPHOLIN-4-YL-ACETIC ACID(3235-69-6)Related Product Information

• 3-Morpholinecarboxylic acid
• 3-morpholinylmethanol
• 4-Benzoylmorpholine
• Morpholin-3-ylMethanol hydrochloride
• 3-cyanoMorpholine
• methyl morpholine-2-carboxylate hydrochloride
• MORPHOLINOFORMAMIDINE HYDROBROMIDE
• chloromethyl morpholine-4-carboxylate
• MORPHOLINO(2-PIPERIDINYL)METHANONE HYDROCHLORIDE
• MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE
• Morpholine-2-carbonitrile
• METHYL N-MORPHOLINOACETATE
• mobecarb
• MORPHOLIN-4-YL-ACETIC ACID
• MORPHOLIN-4-YL-PHENYL-ACETIC ACID
• MORPHOLIN-2-YL-ACETIC ACID ETHYL ESTER
• MORPHOLIN-4-YL-ACETIC ACID,MORPHOLIN-4-YL-ACETIC ACID HYDROCHLORIDE,Morpholin-4-yl-acetic acid hydrochloride ,98%
• (4-CHLORO-PHENYL)-MORPHOLIN-4-YL-ACETIC ACID