Pentoxyverine
Pentoxyverine Basic information
- Product Name:
- Pentoxyverine
- Synonyms:
-
- 1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester
- 1-phenyl-1-cyclopentanecarboxylate
- 1-Phenylcyclopentane-1-Carboxylic acid diethylaminoethoxyethyl ester
- 1-phenylcyclopentane-1-carboxylicaciddiethylaminoethoxyethylester
- 1-phenyl-cyclopentanecarboxylicaci2-(2-(diethylamino)ethoxy)ethylester
- 1-phenylcyclopentanecarboxylicacid2-(2-diethylaminoethoxy)ethylester
- ucb2543
- Urex
- CAS:
- 77-23-6
- MF:
- C20H31NO3
- MW:
- 333.46
- EINECS:
- 201-014-1
- Product Categories:
-
- Miscellaneous Biochemicals
- Mol File:
- 77-23-6.mol
Pentoxyverine Chemical Properties
- Boiling point:
- 165-170 °C (1.33Pa)
- Density
- 1.048±0.06 g/cm3(Predicted)
- refractive index
- 1.4990-1.5010
- storage temp.
- Refrigerator
- solubility
- Dichloromethane (Slightly), Methanol (Slightly)
- pka
- 9.69±0.25(Predicted)
- form
- Oil
- color
- Clear Very Dark Red to Brown
- CAS DataBase Reference
- 77-23-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Cyclopentanecarboxylate, 2-(diethylaminoethoxy)ethyl-1-phenyl-(77-23-6)
Safety Information
- Hazardous Substances Data
- 77-23-6(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 150mg/kg
MSDS
- Language:English Provider:2-(2-Diethylaminoethoxy)ethyl 1-phenylcyclopentane-1-carboxylate
Pentoxyverine Usage And Synthesis
Originator
Asthma ,Nichiiko
Uses
Carbetapentane is an antitussive anticonvulsant sigma site agonist.
Definition
ChEBI: 1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester is a member of benzenes.
Manufacturing Process
1-Phenylcyclopentane carbonitrile was obtained by treatment of phenylacetonitrile with sodium amide and 1,4-dibrombutane.
1-Phenyl-1-cyclopentane carboxylic acid was produced in the result of reaction of 1-phenylcyclopentane carbonitrile with sulfuric acid.
1-Phenyl-1-cyclopentanecarbonyl chloride was obtained by treatment of 1phenyl-1-cyclopentane carboxylic acid with thionyl chloride.
A mixture of 0.5 mol of 1-phenyl-1-cyclopentanecarbonyl chloride and of 0.5 mol of 2-(2-diethylaminoethoxy)ethanol (herein-after referred to as the amino alcohol) in 300 ml of toluene is heated under reflux for 20 h. The mixture is thereafter made alkaline by means of an aqueous solution of caustic soda and decanted; the toluenic layer is washed with water and concentrated in vacuo. The residue is distilled under high vacuum. After two fractional distillations, the 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentane-carboxylate is obtained, in 85% yield. Boiling point 164°C/0.1 mm. Hg.
brand name
Toclase (Pfizer).
Therapeutic Function
Antitussive
Pentoxyverine Preparation Products And Raw materials
Raw materials
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