TYROSINASE Chemical Properties

Melting point:

89-94 °C

storage temp. 

-20°C

form 

lyophilized powder

CAS DataBase Reference

9002-10-2

EPA Substance Registry System

Oxygenase, monophenol mono- (9002-10-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

42

Safety Statements 

22-24/25-45

WGK Germany 

2

F 

10-21

TYROSINASE Usage And Synthesis

Uses

Tyrosinase activity has been assessed in a study that developed an alternative therapeutic agent for treating hyperpigmentation. Tyrosinase has also been used in a study to investigate the oculocutaneous albinism phenotype in the Pakistani population.

General Description

Isoelectric point (pI): 4.7-5
pH optimum is 6-7

Molecular weight: 128 kDa by sedimentation velocity diffusion; 133?kDa by light-scattering measurements, and 119.5 kDa by electrophoresis.

Tyrosinase is a copper-containing oxidase, which has activity for both catechols and cresol. It is responsible for browning reactions. The enzyme is reported to have two binding sites for aromatic substrates and a different binding site for oxygen-copper. The copper is probably Cu(I), with inactivation involving oxidation to Cu(II) ion.

Biochem/physiol Actions

Converts tyrosine to L-DOPA or tyramine to dopamine

TYROSINASE(9002-10-2)Related Product Information

• TERT-BUTYL ISOCYANIDE
• SALCOMINE
• COBALT(II) ACETYLACETONATE
• Benzyl isocyanide
• Ferric acetylacetonate
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• Aluminum acetylacetonate
• Tris(2,4-pentanedionato)chroMiuM(III)
• Ethyl isocyanoacetate
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• METHYL ISOCYANOACETATE
• Tosylmethyl isocyanide
• N-BUTYLISOCYANIDE
• PHENYLSELENOL
• Cupric acetylacetonate
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)