Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antipyretic analgesics >  Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >  Tinoridine

Tinoridine

Basic information Safety Supplier Related

Tinoridine Basic information

Product Name:
Tinoridine
Synonyms:
  • 2-amino-6-(phenylmethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-6-ium-3-carboxylic acid ethyl ester
  • 2-AMINO-3-ETHOXY-CARBONYL-6-BENZYL-4,5,6,7-TETRAHYDROTHIEN.
  • Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
  • tinoridine
  • y-3642
  • 2-amino-3-aethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridin
  • 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine
  • 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine-3-carboxylicacidet
CAS:
24237-54-5
MF:
C17H20N2O2S
MW:
316.42
EINECS:
246-102-0
Mol File:
24237-54-5.mol
More
Less

Tinoridine Chemical Properties

Melting point:
112-113°C
Boiling point:
493.5±45.0 °C(Predicted)
Density 
1.256±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly)
form 
Solid
pka
6.29±0.20(Predicted)
color 
Light Yellow
More
Less

Safety Information

HazardClass 
IRRITANT
HS Code 
2934999090
Toxicity
LD50 in mice, rats (mg/kg): 5400, >10200 orally; 1600, 1250 i.p. (Nakanishi, 1970)
More
Less

Tinoridine Usage And Synthesis

Originator

Nonflamin,Yoshitomi,Japan,1971

Uses

Ethyl 2-Amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (Tinoridine) targets pantothenate synthetase which plays a significant role in the biosynthesis of pantothenate in Mycobacterium tuberculosis (MTB).

Definition

ChEBI: Tinoridine is a thienopyridine.

Manufacturing Process

A solution of 1-benzyl-4-piperidone, ethyl cyanoacetate, powdery sulfur and morpholine in ethanol is heated moderately under reflux for about 20 minutes to dissolve the powdery sulfur. The mixture is heated under reflux for one further hour to complete the reaction. On standing at room temperature, the mixture yields a precipitate. The precipitate is collected by filtration, washed well with methanol and recrystallized from methanol to give 2-amino-6- benzyl-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno(2,3-c)-pyridine as almost colorless needles melting at 112° to 113°C.

brand name

Tinoridine Hydrochloride is JAN.

Therapeutic Function

Antiinflammatory

TinoridineSupplier

Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Email
sales@chemwish.com
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Email
sales@sinch.com.cn
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Email
info@sagechem.com
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Email
sales@shiyabiopharm.com
DebyeTec.com Inc.
Tel
18086626237 18086626237
Email
sales@debyesci.com