2-Mercaptothiazole Chemical Properties

Melting point:

80 °C(Solv: water (7732-18-5))

Boiling point:

194.7±23.0 °C(Predicted)

Density 

1.47±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

8.58±0.20(Predicted)

Appearance

Light brown to brown Solid

InChI

InChI=1S/C3H3NS2/c5-3-4-1-2-6-3/h1-2H,(H,4,5)

InChIKey

OCVLSHAVSIYKLI-UHFFFAOYSA-N

SMILES

S1C=CNC1=S

LogP

1.213 (est)

CAS DataBase Reference

5685-05-2(CAS DataBase Reference)

NIST Chemistry Reference

«delta»4-Thiazoline-2-thione(5685-05-2)

2-Mercaptothiazole Usage And Synthesis

Uses

2-Mercaptothiazole (Thiazoline-2-thione) is a thiazole compound that can be used as a basic structural unit in organic synthesis and is widely used in the pharmaceutical and chemical areas.

Synthesis

The general procedure for the synthesis of thiazole-2(3H)-thione from chloroacetaldehyde and ammonium dithiocarbamate was as follows: a 40% solution of chloroacetaldehyde (0.61 mol) was slowly added to 100 mL of water, keeping the reaction temperature below 5 °C. Subsequently, 67 g of ammonium dithiocarbamate (0.61 mol) was added in batches. After the addition was completed, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 2 h to promote complete reaction. A white solid precipitated during the reaction and the product was collected by filtration. The resulting filter cake was washed sequentially with a small amount of ethanol and cold water to remove impurities. Finally, the product was dried to give 66.2 g of white solid thiazole-2(3H)-thione in 93% yield.

References

[1] Patent: TWI609015, 2017, B. Location in patent: Paragraph 0190

2-Mercaptothiazole(5685-05-2)Related Product Information

• Sodium thioglycolate
• Mercaptoacetic acid
• 2-Mercaptobenzothiazole
• POTASSIUM THIOGLYCOLATE
• Calcium thioglycolate
• 3-Mercaptopropionic acid
• 2-Ethylhexyl mercaptoacetate
• N-tert-Butyl-2-benzothiazolesulfenamide
• 2,2'-Dithiobis(benzothiazole)
• 2-Mercaptoethanol
• 3-(2-BENZOTHIAZOLYLTHIO)PROPIONIC ACID
• 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE
• 2-(Morpholinothio)benzothiazole
• 4-Chloro-2-mercaptobenzothiazole
• 2-Methylmercaptobenzothiazole
• 2,2'-DITHIOBIS(4-METHYLTHIAZOLE)
• N,N-DIISOPROPYLBENZOTHIAZOLE-2-SULFENAMIDE
• 4,5-Dihydro-2-mercaptothiazole