LODOXAMIDE Chemical Properties

Melting point:

>200°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly, Heated)

form 

Solid

color 

Off-White to Pale Orange

Stability:

Hygroscopic

LODOXAMIDE Usage And Synthesis

Uses

Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.

Clinical Use

Lodoxamide, which shows some structural similarities to cromolyn and nedocromil, also is a mast cell stabilizer that inhibits the immediate hypersensitivity reaction, preventing increases in vascular permeability associated with antigen-IgE–mediated responses. Its precise mechanism of action is not completely understood. It is used topically in the eye, principally for conjunctivitis and keratitis associated with vernal allergens.

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