KAN0438757
KAN0438757 Basic information
- Product Name:
- KAN0438757
- Synonyms:
-
- KAN0438757
- Benzoic acid, 4-[[(5'-fluoro-2'-hydroxy[1,1'-biphenyl]-3-yl)sulfonyl]amino]-2-hydroxy-, 2-hydroxyethyl ester
- inhibit,Autophagy,Inhibitor,KAN0438757,KAN-0438757,KAN 0438757
- KAN0438757, 10 mM in DMSO
- 2-Hydroxyethyl 4-(5'-fluoro-2'-hydroxy-[1,1'-biphenyl]-3-ylsulfonamido)-2-hydroxybenzoate
- KAN0438757 (KAN 0438757
- CAS:
- 1451255-59-6
- MF:
- C21H18FNO7S
- MW:
- 447.43
- Mol File:
- 1451255-59-6.mol
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KAN0438757 Chemical Properties
- Boiling point:
- 680.0±65.0 °C(Predicted)
- Density
- 1.507±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 130 mg/mL (290.55 mM)
- form
- Solid
- pka
- 6.42±0.10(Predicted)
- color
- White to off-white
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KAN0438757 Usage And Synthesis
Uses
KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1].
in vivo
KAN0438757 (i.p., 10; 25; 50 mg/kg) is well tolerated, and shows no relevant systemic toxic effects in C57BL6/N mice[2].
References
[1] Gustafsson NMS, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018 Sep 24;9(1):3872. DOI:10.1038/s41467-018-06287-x
[2] De Oliveira T, et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Cancers (Basel). 2021 Feb 28;13(5):1011. DOI:10.3390/cancers13051011
KAN0438757Supplier
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 0-2022843681 15618226720
- chaolaichem@foxmail.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
CR Corporation Limited
- Tel
- +8613062833949
- fred.wen@crcorporation.cn