2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol hydrochloride Chemical Properties

form 

Solid

color 

White to off-white

2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol hydrochloride Usage And Synthesis

Uses

SMARCA-BD ligand 1 for PROTAC dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

References

[1] Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680. DOI:10.1038/s41589-019-0294-6

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