Leonurine hydrochloride
Leonurine hydrochloride Basic information
- Product Name:
- Leonurine hydrochloride
- Synonyms:
-
- Leonurine 4-Guanidino-1-butanol syringate
- SCM-198
- leonurine hydrochloride
- 4-Guanidino-1-butanol syringate
- 4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxy-benzoate hydrochloride
- Leonurine
- LEONURINE HCL
- 4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester
- CAS:
- 24697-74-3
- MF:
- C14H21N3O5
- MW:
- 311.33
- EINECS:
- 683-174-6
- Product Categories:
-
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- chemical reagent
- pharmaceutical intermediate
- standardized herbal extract
- Mol File:
- 24697-74-3.mol
Leonurine hydrochloride Chemical Properties
- Melting point:
- 238 °C
- Boiling point:
- 496.7±55.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: soluble2mg/mL, clear (warmed)
- pka
- 8.26±0.25(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- WNGSUWLDMZFYNZ-UHFFFAOYSA-N
Leonurine hydrochloride Usage And Synthesis
Description
An amorphous alkaloid, leonurine has been obtained from the leaves of Leonurus sibiricus L. and is characterized as the crystalline hydrochloride hydra te, m.p. 19l-4°C. Hydrolysis yields syringic acid and Q-hydroxybutylguanidine. The total synthesis of the alkaloid has been achieved, confirming the above structure.
Uses
Leonurine is a pseudoalkaloid that has been isolated from Leonotis leonurus. A natural product with antioxidant, anti-inflammatory and cardioprotective properties for the treatment of wild variety of conditions including stroke, cerebral thrombosis and cardiovascular diseases.
Uses
Leonurine Hydrochloride is an alkaloid plant extract used in the treatment of uterine disorders. Used in the modification of uterine contractions in rats.
Definition
ChEBI: Leonurine is a trihydroxybenzoic acid.
References
Kubota, Nakajima., Nippon Yakubusugaku Zasshi., 163 (1930)
Goto et al., Tetrahedron Lett., 545 (1962)
Total synthesis:
Kishi et al., Tetrahedron Lett., 637 (1968)
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