Apremilast-d8 Usage And Synthesis

Uses

Apremilast-d8 (CC-10004-d8) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249. DOI:10.1186/s13075-015-0771-6
[3] Chen LG, et al. Determination of Apremilast in Rat Plasma by UPLC-MS-MS and Its Application to a Pharmacokinetic Study. J Chromatogr Sci. 2016 Sep;54(8):1336-40. DOI:10.1093/chromsci/bmw072

Apremilast-d8(1258597-45-3)Related Product Information

• Apremilast Impurity 15
• Apremilast impurity 18
• Apremilast Impurity 25
• Apremilast Impurity 28
• (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
• Apremilast impurity 19
• Apremilast Impurity 14
• 1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanol
• (R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine
• Apremilast Impurity 34
• 1-(3,4-Diethoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
• BenzeneMethanaMine, 4-ethoxy-3-Methoxy-a-[(Methylsulfonyl)Methyl]-
• Apremilast Impurity 4
• 4-Nitrophthalic acid
• 1-Methyl-3-nitrophthalate
• 4-acetamidophthalic acid
• 1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-
• Apremilast Impurity 19