NAT10 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

N-acetyltransferase 10, also known as human N-acetyltransferase-like protein, is an acetyltransferase that increases telomerase activity through the activation of the TERT promoter. NAT10 localizes to the midbody in late phase mitosis to help achieve cytokinesis. It has been found that DNA damage can actually increase NAT10-dependent acetylation of alpha-tubulin, resulting in increased stability of the protein. This increased stability of microtubules has been linked to the sequestration of the nuclear import factor transportin-1 in the premature aging disease, progeria. NAT10 can also function as an acetyltransferase for both rRNA and mRNA. The acetylation of the 18 S rRNA helps in rRNA processing and ribosome biogenesis, and this process can be disrupted by opposing activity of the deacetylase SirT1 in response to stress. mRNA acetylation by NAT10 plays a role in translation efficiency and mRNA stability. NAT10 is overexpressed in many different cancer types, making it a good potential therapeutic target.

References

[1] Lv, J. et al. (2003) Biochem Biophys Res Commun 311, 506-13.
[2] Shen, Q. et al. (2009) Exp Cell Res 315, 1653-67.
[3] Liu, H. et al. (2007) Mol Cell Biochem 300, 249-58.
[4] Larrieu, D. et al. (2018) Sci Signal 11, eaar5401. doi: 10.1126/scisignal.aar5401.
[5] Wilson, K.L. (2018) Sci Signal 11, eaat9448. doi: 10.1126/scisignal.aat9448.
[6] Ito, S. et al. (2014) J Biol Chem 289, 35724-30.
[7] Arango, D. et al. (2018) Cell 175, 1872-1886.e24.
[8] Dominissini, D. and Rechavi, G. (2018) Cell 175, 1725-1727.
[9] Liu, X. et al. (2018) Nucleic Acids Res 46, 9601-9616.
[10] Liang, P. et al. (2020) Curr Probl Cancer 44, 100491.

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