HCV E2 Usage And Synthesis

Description

Recombinant Hepatitis C Virus E2 Genotype-1 produced in E. coli is a single polypeptide chain containing 226 amino acids (aa 482-671) and having a molecular mass of 25.4kDa (NCBI Accession#NP_671491).
HCV E2 is fused to a 36 amino acid His-tag at N-terminus.

Source

Escherichia Coli

Background

E1 and E2 glycoproteins form a heterodimer which is involved in virus attachment to the host cell, virion internalization via clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, however this binding insufficient for infection, some additional liver specific cofactors may be required. The fusion function may perhaps be conducted by E1. E2 hinders human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively located on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow seizure of circulating HCV particles by these cells and subsequent diffusion to permissive cells.

HCV E2()Related Product Information

• SW 1417
• MLE-12
• RMC-1
• HCV NS5a
• HCV NS5b
• HCV-NS4a
• SUPB15
• KBM-7
• HCC2279
• Bone Marrow Mesenchymal Stem Cells
• HCV-NS3
• Htori-3
• OCI-Ly18
• Walker256
• M-NFS-60 mouse myeloid leukemia cells
• NA
• NA
• TREGS mouse regulatory T cells