CC-90009
CC-90009 Basic information
- Product Name:
- CC-90009
- Synonyms:
-
- CC-90009
- CC-90009; CC 90009; CC90009;
- Cereblon modulator 1
- Benzeneacetamide, 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-
- Cereblon modulator 1（CC-99）
- Eragidomide
- Eragidomide(CC-90009)
- proteasome-mediated,CRBN,degradation,Eragidomide,CC-90009,Molecular Glues,E3 ligase-recruiting Moiety,IKZF3,IRF4,IKZF1,c-myc,Inhibitor,anti-cancer,Ligands for E3 Ligase,inhibit,CC 90009,Apoptosis,CC90009,T-lymphocytes
- CAS:
- 1860875-51-9
- MF:
- C22H18ClF2N3O4
- MW:
- 461.85
- Product Categories:
-
- APIS
- Mol File:
- 1860875-51-9.mol
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CC-90009 Chemical Properties
- Boiling point:
- 770.1±60.0 °C(Predicted)
- Density
- 1.466±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (541.30 mM)
- form
- A crystalline solid
- pka
- 10.66±0.40(Predicted)
- color
- Off-white to light yellow
- InChIKey
- PWBHUSLMHZLGRN-UHFFFAOYSA-N
- SMILES
- O=C1C2=CC=C(CNC(=O)C(C3C=CC(Cl)=CC=3)(F)F)C=C2CN1C1CCC(=O)NC1=O
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CC-90009 Usage And Synthesis
Uses
Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2].
IC 50
Cereblon
References
[1] Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. DOI:10.1182/blood.2020008676
[2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64(4):1835-1843. DOI:10.1021/acs.jmedchem.0c01489
CC-90009Supplier
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