Tyrphostin AG1433
Tyrphostin AG1433 Basic information
- Product Name:
- Tyrphostin AG1433
- Synonyms:
-
- 1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-
- cytotoxicity,PDGFRβ,Tyrphostin AG 1433,AG-1433,Tyrphostin AG1433,VEGFR,AG 1433,kinases,Vascular endothelial growth factor receptor,SU 1433,Tyrphostin AG-1433,Platelet-derived growth factor receptor,angiogenesis,tyrosine,inhibit,VEGFR-2,Inhibitor,ATM,PDGFR,SU-1433
- Tyrphostin A 1433
- CAS:
- 168835-90-3
- MF:
- C16H14N2O2
- MW:
- 266.29
- Mol File:
- 168835-90-3.mol
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Tyrphostin AG1433 Chemical Properties
- Melting point:
- 280-282 °C
- Boiling point:
- 490.9±45.0 °C(Predicted)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 62.5 mg/mL (234.71 mM)
- pka
- 8.32±0.20(Predicted)
- form
- Solid
- color
- Light yellow to khaki
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Tyrphostin AG1433 Usage And Synthesis
Biological Activity
Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation.
in vivo
Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.
target
| Flk-1 < span> 9.3 μM (IC 50 ) | PDGFRβ 5 μM (IC 50 ) |
Tyrphostin AG1433Supplier
Tianjin Kailiqi Biotechnology Co., Ltd.
- Tel
- 15076683720
- klq@cw-bio.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Zhengzhou Huiju Chemical Co., Ltd.
- Tel
- 0371-55900031 18137872243
- 2853979815@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
DC Chemicals
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com