Desmethyl Cariprazine Chemical Properties

Melting point:

226 - 230°C

Boiling point:

596.8±50.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Dichloromethane (Slightly, Heated), DMF (Slightly, Heated), DMSO (Slightly, Heat

pka

14.45±0.40(Predicted)

form 

Solid

color 

White to Off-White

Desmethyl Cariprazine Usage And Synthesis

Uses

Desmethyl Cariprazine, is a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.

IC 50

D₃ Receptor: 0.085 nM (Ki); D₂ Receptor: 0.49 nM (Ki); 5-HT_1A Receptor: 2.6 nM (Ki)

Desmethyl Cariprazine(839712-15-1)Related Product Information

• Cariprazine D8
• Cariprazine
• Nsc175383
• Cariprazine intermediate 2
• Piperazine, 1-(2-chloroethyl)-4-(2,3-dichlorophenyl)-
• Urea, N,N'-bis[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-
• Urea, N,N-dimethyl-N'-[trans-4-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]cyclohexyl]-
• ethyl dimethylcarbamate
• 3,3-dimethyl-1-[(1r,4r)-4-(2-hydroxyethyl)cyclohexyl]urea
• Cyclohexaneethanol, 4-amino-, hydrochloride (1:1), trans-