Methyl-(Tetrahydro-Pyran-4-Yl)-Amine Hcl Chemical Properties

Boiling point:

165.0±33.0 °C(Predicted)

Density 

0.93±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

10.01±0.20(Predicted)

form 

liquid

color 

Clear, colourless

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

RIDADR 

UN2735

Hazard Note 

Harmful

HazardClass 

IRRITANT

HS Code 

2932990090

Methyl-(Tetrahydro-Pyran-4-Yl)-Amine Hcl Usage And Synthesis

Uses

Methyl-(Tetrahydro-Pyran-4-Yl)-Amine Hcl is mainly used in dyes, pesticides, etc., but also food additives, flavours, and fragrances.

Synthesis

To a stirred solution of tetrahydro-4H-pyran-4-one (1 g, 10 mmol) in tetrahydrofuran (THF, 10 mL) was added slowly and dropwise at room temperature methylamine (0.62 g, 20 mmol, 2 M THF solution), followed by acetic acid (0.5 mL). The reaction mixture was stirred continuously for 1 hour. Subsequently, sodium cyanoborohydride (0.7 g, 12 mmol) was added to the reaction mixture at 0 °C and stirring was continued for 16 h at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm the completion of the reaction. Eventually, the target product N-methyltetrahydro-2H-pyran-4-amine (1 g) was isolated as a yellow liquid. Mass spectrum (ESI) m/z 115 [M]+.

References

[1] Patent: US2016/289171, 2016, A1. Location in patent: Paragraph 1794
[2] Patent: US2017/348315, 2017, A1. Location in patent: Paragraph 0322

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