NOC-18
NOC-18 Basic information
- Product Name:
- NOC-18
- Synonyms:
-
- DETA NONOate,97%
- NOC-18;DIETHYLENETRIAMINE NONOATE;3,3-BIS(AMINOETHYL)-1-HYDROXY-2-OXO-1-TRIAZENE
- DIETHYLENETRIAMINE NONOATE
- DETA/NO
- DETA NONOATE
- NOC-18
- (Z)-1-[N-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
- (Z)-1-[2-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
- CAS:
- 146724-94-9
- MF:
- C4H13N5O2
- MW:
- 163.18
- Product Categories:
-
- Nitric Oxide Reagents
- Mol File:
- 146724-94-9.mol
NOC-18 Chemical Properties
- Melting point:
- 98-106 °C
- Boiling point:
- 290.26°C (rough estimate)
- Density
- 1.3102 (rough estimate)
- refractive index
- 1.8000 (estimate)
- storage temp.
- -20°C
- solubility
- H2O: >20 mg/mL
- form
- solid
- pka
- 4.50±0.69(Predicted)
- color
- off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.
- CAS DataBase Reference
- 146724-94-9
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
NOC-18 Usage And Synthesis
Description
DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
Chemical Properties
White Powder
Uses
A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.
Uses
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.
Definition
ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.
Biochem/physiol Actions
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.
References
1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281
NOC-18Supplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
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- 021-61259108 18621169109
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- Tel
- 821-50328103-801 18930552037
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- Tel
- 800-810-5118
- cnchemical@thermofisher.com
- Tel
- 15221275939 15221275939
- shenlinxing@macklin.cn
NOC-18(146724-94-9)Related Product Information
- DEA NONOate
- GEA 5024
- Sodium nitroprusside dihydrate
- DPTA NONOATE
- SPERMINE NONOATE
- NOC-7
- MAHMA NONOATE
- 4-(N-CYANOMETHYL-N-NITROSO)AMINOMORPHOLINE
- S-NITROSOGLUTATHIONE
- NOC-5
- BETA-GAL-NONOATE
- NOR-3
- PAPA NONOATE
- GEA 3162
- V-PYRRO/NO
- NOC-18
- 1-HYDROXY-2-OXO-3,3-BIS(2-AMINO ETHYL)-1-TRIAZENE (NOC-18)
- NOC 18