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NOC-18

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NOC-18 Basic information

Product Name:
NOC-18
Synonyms:
  • DETA NONOate,97%
  • NOC-18;DIETHYLENETRIAMINE NONOATE;3,3-BIS(AMINOETHYL)-1-HYDROXY-2-OXO-1-TRIAZENE
  • DIETHYLENETRIAMINE NONOATE
  • DETA/NO
  • DETA NONOATE
  • NOC-18
  • (Z)-1-[N-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
  • (Z)-1-[2-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
CAS:
146724-94-9
MF:
C4H13N5O2
MW:
163.18
Product Categories:
  • Nitric Oxide Reagents
Mol File:
146724-94-9.mol
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NOC-18 Chemical Properties

Melting point:
98-106 °C
Boiling point:
290.26°C (rough estimate)
Density 
1.3102 (rough estimate)
refractive index 
1.8000 (estimate)
storage temp. 
-20°C
solubility 
H2O: >20 mg/mL
form 
solid
pka
4.50±0.69(Predicted)
color 
off-white
Stability:
Stable for 1 year from date of purchase as supplied. Store under inert gas. Solutions must be made fresh immediately before use and cannot be stored.
CAS DataBase Reference
146724-94-9
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
KH2502500
HS Code 
29270000

MSDS

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NOC-18 Usage And Synthesis

Description

DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.

Chemical Properties

White Powder

Uses

A stable NO-amine complex which can release NO spontaneously under physiological conditions. The half life of NO release in 0.1 M PBS at (pH7.4) at 37?C for 0.1mM NOC 5 is 21 hours. Other applications include the induction of dose dependent apoptosis in macrophages, and inhibition of lipoprotein oxidation induced by Cu2+ in vitro.

Uses

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as a nitric oxide donor supplement for neuronal culture. It has also been used as a nitric oxide donor to study the effects of protein S-nitrosation (SNO) after nitrite treatment.

Definition

ChEBI: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.

Biochem/physiol Actions

3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.

References

1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281

NOC-18Supplier

J & K SCIENTIFIC LTD.
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