Tigogenin
Tigogenin Basic information
- Product Name:
- Tigogenin
- Synonyms:
-
- TIGOGENIN
- (25r)-5-alpha-spirostan-3-beta-o
- 25R,5ALPHA-SPIROSTAN-3BETA-OL
- 5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL
- (25R)-5-Spirostan-3-ol
- (3-beta,5-alpha,25r)-spirostan-3-o
- 5-alpha-spirostan-3-beta-ol
- 5alpha-Spirostan-3beta-ol, (25R)-
- CAS:
- 77-60-1
- MF:
- C27H44O3
- MW:
- 416.64
- EINECS:
- 201-041-9
- Product Categories:
-
- Miscellaneous Natural Products
- Mol File:
- 77-60-1.mol
Tigogenin Chemical Properties
- Melting point:
- 202-204°C
- alpha
- -68 º (c=0.8g/100ml, CHCl3)
- Boiling point:
- 474.91°C (rough estimate)
- Density
- 1.0362 (rough estimate)
- refractive index
- 1.4700 (estimate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly)
- pka
- 15.14±0.70(Predicted)
- form
- Solid
- color
- Off-White
- CAS DataBase Reference
- 77-60-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Tigogenin(77-60-1)
MSDS
- Language:English Provider:(25R)-5alpha-Spirostan-3beta-ol
Tigogenin Usage And Synthesis
Description
Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.
Chemical Properties
mp 196-208C° LOD ≤0.5%
Uses
Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.
Definition
ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.
Tigogenin Preparation Products And Raw materials
Preparation Products
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