2-METHOXY-5-NITROBENZALDEHYDE Chemical Properties

Melting point:

89-92 °C (lit.)

Boiling point:

336.7±27.0 °C(Predicted)

Density 

1.322±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

very soluble in Dimethylformamide

form 

powder to crystal

color 

White to Light yellow to Light orange

InChI

1S/C8H7NO4/c1-13-8-3-2-7(9(11)12)4-6(8)5-10/h2-5H,1H3

InChIKey

YWVSKFXYEWMHEO-UHFFFAOYSA-N

SMILES

COc1ccc(cc1C=O)[N+]([O-])=O

CAS DataBase Reference

25016-02-8

EPA Substance Registry System

Benzaldehyde, 2-methoxy-5-nitro- (25016-02-8)

Safety Information

WGK Germany 

3

TSCA 

TSCA listed

HS Code 

2913000090

Storage Class

13 - Non Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

2-METHOXY-5-NITROBENZALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-methoxy-5-nitrobenzaldehyde from 5-nitrosalicylaldehyde and iodomethane: Sodium hydride (NaH, 246 mg) and iodomethane (2.56 g) were added to a solution of 5-nitrosalicylaldehyde (1.00 g, 6.0 mmol) in N,N-dimethylformamide (DMF, 20 ml). The reaction mixture was stirred at 0°C for 8.5 hours. After completion of the reaction, the reaction mixture was extracted with ether and the organic phase was washed sequentially with aqueous sodium bicarbonate, saturated brine and 5% hydrochloric acid/saturated brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-methoxy-5-nitrobenzaldehyde (0.95 g, 87.8% yield) as yellow needle-like crystals. The product was characterized by 1H NMR (CDCl3): δ 10.45 (s, 1H), 8.70 (d, J = 2.9Hz, 1H), 8.45 (dd, J = 8.8, 2.9Hz, 1H), 7.14 (d, J = 8.8Hz, 1H), 4.08 (s, 3H).

References

[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 15, p. 3435 - 3438
[2] Patent: US2013/261295, 2013, A1. Location in patent: Paragraph 0166; 0167
[3] Journal of the American Chemical Society, 2017, vol. 139, # 19, p. 6654 - 6662
[4] Patent: US5837711, 1998, A
[5] Journal of the Chemical Society, 1951, p. 2462,2466

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