METHYL 6-AMINOCAPROATE HYDROCHLORIDE Chemical Properties

Melting point:

117-124 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

BRN 

3687692

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

WGK Germany 

3

F 

3

MSDS

• Language:English Provider:SigmaAldrich

METHYL 6-AMINOCAPROATE HYDROCHLORIDE Usage And Synthesis

Uses

Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Thionyl chloride (1.4 eq.) was slowly added dropwise to a methanolic suspension of 6-aminohexanoic acid (1 eq.) at 0 °C while maintaining stirring. The reaction mixture was continued to be stirred overnight at room temperature. Subsequently, the solvent and unreacted thionyl chloride were removed by distillation under reduced pressure to give methyl 6-aminohexanoate hydrochloride.

References

[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4737 - 4740
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 16, p. 6516 - 6532
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 20, p. 6094 - 6103
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 16, p. 5950 - 5961
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3591 - 3594

METHYL 6-AMINOCAPROATE HYDROCHLORIDE(1926-80-3)Related Product Information

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