2-Hexanone Chemical Properties

Melting point:

-57 °C

Boiling point:

127 °C(lit.)

Density 

0.812 g/mL at 25 °C(lit.)

vapor pressure 

10 mm Hg ( 39 °C)

refractive index 

n20/D 1.401(lit.)

Flash point:

95 °F

storage temp. 

2-8°C

solubility 

Soluble in acetone, ethanol, and ether (Weast, 1986)

pka

-8.30 (quoted, Riddick et al., 1986)

form 

Liquid

color 

Clear colorless to light yellow

Odor

at 1.00 % in dipropylene glycol. fruity fungal meaty buttery

Odor Type

fruity

Odor Threshold

0.024ppm

Water Solubility 

2 g/100 mL (20 ºC)

Merck 

14,6033

BRN 

1737676

Henry's Law Constant

24.4 at 37 °C (static headspace-GC, Bylaite et al., 2004)

Exposure limits

NIOSH REL: TWA 1 ppm (4 mg/m³), IDLH 1,600 ppm; OSHA PEL: TWA 100 ppm (410 mg/m³); ACGIH TLV: TWA 5 ppm, STEL 10 ppm (adopted).

Dielectric constant

14.6（15℃）

Stability:

Stable. Flammable. Incompatible with oxidizing agents, strong bases, reducing agents.

InChIKey

QQZOPKMRPOGIEB-UHFFFAOYSA-N

LogP

1.380

CAS DataBase Reference

591-78-6(CAS DataBase Reference)

NIST Chemistry Reference

2-Hexanone(591-78-6)

EPA Substance Registry System

2-Hexanone (591-78-6)

Safety Information

Hazard Codes 

T,F

Risk Statements 

10-48/23-62-67-39/23/24/25-23/24/25-11

Safety Statements 

36/37-45-16-7

RIDADR 

UN 1224 3/PG 3

OEB

B

OEL

TWA: 1 ppm (4 mg/m3)

WGK Germany 

1

RTECS 

MP1400000

Autoignition Temperature

530 °C

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29141900

Hazardous Substances Data

591-78-6(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 2.59 g/kg (Smyth)

IDLA

1,600 ppm

MSDS

• Language:English Provider:2-Hexanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Hexanone Usage And Synthesis

Description

2-Hexanone has been used as a solvent for both cellulose- and resin-based coating systems. In the early 1970s, a number of workers in the print department of a coated fabrics plant developed severe peripheral neuropathy from an unknown cause. In search of an etiological agent, and in the absence of other neurotoxicants, 2-hexanone was implicated as it was recently substituted for methyl isobutyl ketone in the manufacturing process. Similar observations in workers exposed to 2-hexanone may have resulted in the decline in production and use in the United States.

Chemical Properties

MNBK is a colorless liquid with an acetonelike odor. The odor threshold is 0.08 ppm.

Chemical Properties

2-Hexanone is a colorless to pale yellow liquid with a sharp odor. It dissolves very easily in water and is miscible in ethanol, methanol, and benzene. 2-Hexanone evaporates easily into the air as a vapor. It is stable, flammable, and incompatible with oxidizing agents, strong bases, and reducing agents. 2-Hexanone is a waste product of wood pulping, coal gasifi cation, and oil shale operations. Formerly, 2-hexanone was in use as a paint and paint thinner with other chemical substances, and to dissolve oils and waxes.and is used as a solvent and organic syn- thesis intermediates. However, the industrial uses of 2-hexanone is now very much restricted.

Physical properties

Clear, colorless to pale yellow, flammable liquid with an odor resembling acetone and 2-butanone. Nagata and Takeuchi (1990) reported an odor threshold concentration of 24 ppb_v. Amoore and Hautala (1983) reported odor threshold concentrations of 250 μg/L and 76 ppb_v in water and air, respectively.

Uses

Methyl butyl ketone (MBK) is used as asolvent for nitrocellulose, resins, lacquers,oils, fats, and waxes.

Uses

As industrial solvents for adhesives, lacquers, paint removers, and acrylic coatings

Uses

2-Hexanone is used in various organic chemical syntheses. It is used in the synthesis of (+/-)-monomorine. It is also used in the preparation of alcohols by transfer hydrogenation of ketones.

Definition

ChEBI: 2-Oxohexane is a ketone.

Production Methods

MnBK can be produced by a reaction between acetic acid and ethylene under pressure MnBK can be produced by a reaction between acetic acid and ethylene under pressure.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 5181, 1983 DOI: 10.1016/S0040-4039(00)88391-4
Journal of the American Chemical Society, 89, p. 5708, 1967 DOI: 10.1021/ja00998a040

General Description

A clear colorless liquid. Flash point 95°F. Less dense than water. Vapors heavier than air.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

2-Hexanone is incompatible with oxidizing agents. 2-Hexanone may also react with strong bases and reducing agents.

Hazard

Flammable, moderate fire risk, explosive limits 1.2–8% in air. Irritant to eyes and mucous membranes, narcotic in high concentration, absorbed by skin. Causes peripheral neuropathy and testicular damage.

Health Hazard

Chronic exposure to MBK via inhalationor skin absorption can cause disordersof the peripheral nervous system andneuropathic diseases. The symptoms inhumans, depending on the severity ofexposure, were parasthesias in the handsor feet, muscle weaknesses, weakness inankles and hand, and difficulty in grasping heavy objects. Animal studies indicatethat prolonged exposure to this compoundat a concentration of 200–1300 ppm for4–12 weeks can result in neuropathy.Neurotoxicity is attributed to its primarymetabolite, 2,5-hexanedione. Improvementin conditions can occur slowly over monthsafter cessation of exposure. Acute exposureto high concentrations, 1000 ppm, for severalminutes can cause irritation of the eyes andnose in humans. Inhalation to 20,000 ppmfor 30 minutes caused narcosis in guineapigs and prolonged exposure for 70 minuteswas lethal. The acute oral toxicity in ratswas low.
LD50 value, oral (rats): 2600 mg/kg.

Health Hazard

Inhalation of high concentrations of vapor may result in narcosis; peripheral neuropathy may develop. Ingestion of large amounts may cause some systemic injury. Contact with eyes causes mild to moderate irritation. Liquid irritates skin; prolonged or repeated contact may cause defatting of the skin with resultant dermatitis.

Fire Hazard

2-Hexanone is flammable.

Potential Exposure

The material is used as a solvent

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Environmental Fate

Biological. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM 2-hexanone) and ThOD were 5.22 and 61.4%, respectively (Vaishnav et al., 1987).
Photolytic. A second-order photooxidation rate constant of 8.97 x 10^-12 cm³/molecule?sec for the reaction of 2-hexanone and OH radicals in the atmosphere at 299 K was reported by Atkinson (1985).
Chemical/Physical. 2-Hexanone will not hydrolyze because it has no hydrolyzable functional group (Kollig, 1995).

storage

2-Hexanone should be kept stored in a tightly closed container, in a cool, dry place, away from sources of ignition.

Shipping

UN1224 Ketones, liquid, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, Technical Name Required

Toxicity evaluation

Regardless of the route of exposure, both human and animal studies indicate that the nervous system is the target organ of 2-hexanone toxicity with its metabolite, 2,5-hexanedione, serving as the neurotoxic agent. 2,5-Hexanedione binds covalently to axonal components of the nerve tissue. In vitro studies have shown that this metabolite reacts with the nucleophilic lysine 3-amino groups to ultimately form 2,5-dimethylpyrrole adducts with neurofilaments. Neurofilament aggregates concentrate in the distal subterminal axon, resulting in axonal swelling, or distal axonopathy, just proximal to the nodes of Ranvier. These reactions may lead to the manifestation of peripheral neuropathy.

Incompatibilities

Violent reaction with oxidizers. May form unstable peroxides. Attacks plastics.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Precautions

Occupational workers should be careful when using and handling 2-hexanone. Workers should wash thoroughly after handling the chemical substance. Workers should avoid contact of 2-hexanone with the eyes, skin, and clothing and also avoid contact with heat, sparks, and flame.

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