1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride Chemical Properties

Melting point:

172-174°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Slightly)

form 

Solid

color 

White to Pale Yellow

CAS DataBase Reference

90604-02-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37

Hazard Note 

Irritant

HS Code 

2934999090

1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride Usage And Synthesis

Uses

1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride is a vital compound and can be used to synthesise 1-Benzhydrylazetidin-3-one and 1-benzhydrylazetidin-3-ol.

Synthesis

General procedure for the synthesis of 1-(diphenylmethyl)-3-hydroxyazetidine hydrochloride from 1-diphenylmethyl-3-hydroxyazetidine: 1-(diphenylmethyl)-3-hydroxyazetidine (9.70 g) was suspended in a 4.5 M hydrochloric acid solution of ethyl acetate (35 mL) at room temperature and the reaction was stirred for 10 minutes. Subsequently, the solvent was removed by evaporation to give 1-(diphenylmethyl)-3-hydroxyazetidine hydrochloride (12.0 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6, with TMS as internal standard) with the following chemical shifts (ppm): δ 7.30-7.70 (10H, m, arylhydrogen), 5.85 (1H, s, CH), 5.80 (1H, d, OH), 4.46 (1H, m, CH), 3.70-4.20 (4H, m, CH2 ).

References

[1] Patent: WO2007/118830, 2007, A1. Location in patent: Page/Page column 91

1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride(90604-02-7)Related Product Information

• 3-Hydroxyazetidine hydrochloride
• 3-AZETIDINOL
• 1-(Diphenylmethyl)-3-hydroxyazetidine
• Azetidine hydrochloride