HINOKIFLAVONE Chemical Properties

Melting point:

353-355°C

Boiling point:

841.5±65.0 °C(Predicted)

Density 

1.622

storage temp. 

2-8°C

solubility 

Acetone: Soluble; Chloroform: Soluble; Dichloromethane: Soluble; DMSO: Soluble; Ethyl Acetate: Soluble

form 

A solid

pka

5.70±0.40(Predicted)

color 

Light yellow to yellow

LogP

5.528 (est)

HINOKIFLAVONE Usage And Synthesis

Definition

ChEBI: A biflavonoid that is apigenin substituted by a 4-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)phenoxy group at position 6. A diflavonyl ether, it is isolated from Rhus succedanea and has been found to possess significant cytotoxic otential.

Biological Activity

Hinokiflavone is a plant biflavone th at exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.

HINOKIFLAVONE(19202-36-9)Related Product Information

• (4-PHENOXYPHENYL)METHANOL
• HINOKIFLAVONE
• 6-METHOXYFLAVONE
• 2',5'-Dihydroxyacetophenone
• Monobenzone
• 3-Phenoxybenzaldehyde
• 3-PHENOXYTOLUENE
• 4-PHENOXYSTYRENE
• 4-Phenoxyphenol
• HISPIDULIN
• 2-Hydroxy-5-methoxybenzaldehyde
• Baicalein
• 2-Phenoxyphenol
• O-EUGENOL
• 2',3',4'-TRIHYDROXYACETOPHENONE
• SCUTELLAREIN
• 2,5-Dimethoxybenzaldehyde
• Eugenol