2-AMINO-4,6-DIFLUOROBENZOIC ACID Chemical Properties

Boiling point:

305.8±42.0 °C(Predicted)

Density 

1.536

storage temp. 

RT, protect from light

form 

wooly crystalline powder

pka

3.95±0.10(Predicted)

color 

Light yellow/gold

Sensitive 

Air Sensitive

Safety Information

Hazard Codes 

Xi

HS Code 

2916310000

2-AMINO-4,6-DIFLUOROBENZOIC ACID Usage And Synthesis

Uses

2-Amino-4,6-difluorobenzoic acid is an important pharmaceutical and pesticide intermediate, and it can also be used in liquid crystal materials. It has the advantages of high value and good market prospects.

Synthesis

Stage 3: Synthesis of 2-amino-4,6-difluorobenzoic acid A solution of sodium hydroxide (6.70 g, 167 mmol) and 30% hydrogen peroxide (6.7 mL) in water (60 mL) was added dropwise to a suspension of the stage 2 product (4.58 g, 25 mmol) in water (125 mL) and the reaction was carried out at 0 °C. Subsequently, the reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the pH was adjusted to 3 with formic acid (~11 mL, taking care to control the rate of addition to prevent violent foaming), at which point the target compound began to precipitate. The precipitate was collected by filtration and dried in a desiccator using phosphorus pentoxide to give 3.72 g of white solid product (86% yield). The melting point of the product was 198-202 °C.

References

[1] Patent: US2008/293749, 2008, A1. Location in patent: Page/Page column 14
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6465 - 6488
[3] Organic Process Research and Development, 2010, vol. 14, # 5, p. 1078 - 1087

2-AMINO-4,6-DIFLUOROBENZOIC ACID(126674-77-9)Related Product Information

• 4-AMINO-2,3-DIFLUOROBENZOIC ACID
• 4,5-difluoroanthranilic acid (2-amino-4,5-difluorobenzoic acid),2-AMINO-4,5-DIFLUOROBENZOIC ACID
• 4-Amino-2,5-Difluorobenzoic Acid
• 2,3,4,5-TETRAFLUORO-6-NITROBENZOIC ACID
• 2-AMINO-3,4,5,6-TETRAFLUOROBENZOIC ACID
• 2-AMINO-3,4-DIFLUOROBENZOIC ACID
• 2,4,5-TRIFLUORO-3-METHYL-6-NITROBENZOIC ACID
• 2-AMINO-4,6-DIFLUOROBENZOIC ACID
• 2-amino-3,6-difluorobenzoic acid
• 2-amino-3,5-difluorobenzoic acid
• 2,4,5-TRIFLUORO-3-METHOXY-6-NITROBENZOIC ACID
• 5-AMINO-2,3-DIFLUOROBENZOIC ACID
• 3-Amino-2,6-Difluorobenzoic Acid
• 5-Amino-2,4-difluorobenzoic acid methyl ester
• 6-[(2,2-DIMETHYLPROPANOYL)AMINO]-2,3-DIFLUOROBENZOIC ACID
• 5,7-DIFLUORO-1H-BENZO[D][1,3]OXAZINE-2,4-DIONE
• 3-Amino-2,6-difluorobenzoic acid methyl ester
• 3-Amino-2,6-Difluorobenzoic Acid3