(S)-(+)-1-Amino-2-propanol Chemical Properties

Melting point:

24-26 °C(lit.)

Boiling point:

160 °C(lit.)

alpha 

18 º (c=1.8, H2O)

Density 

0.954 g/mL at 25 °C(lit.)

vapor density 

2.6 (vs air)

vapor pressure 

<1 mm Hg ( 20 °C)

refractive index 

n20/D 1.4437(lit.)

Flash point:

169 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Sparingly), Water (Sparingly)

pka

12.92±0.35(Predicted)

form 

Liquid After Melting

color 

Clear colorless to pale yellow

Specific Gravity

0.954

optical activity

[α]20/D +18°, c = 1.8 in H2O

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

1718868

Cosmetic Ingredient Review (CIR)

(S)-(+)-1-Amino-2-propanol (2799-17-9)

InChI

1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3/t3-/m0/s1

InChIKey

HXKKHQJGJAFBHI-VKHMYHEASA-N

SMILES

C[C@H](O)CN

LogP

-1.127 (est)

CAS DataBase Reference

2799-17-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Propanol, 1-amino-, (S)-(2799-17-9)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

23-26-36-45

RIDADR 

UN 3259 8/PG 2

WGK Germany 

1

RTECS 

UA5775000

F 

10-34

HazardClass 

8

PackingGroup 

III

HS Code 

29221980

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

MSDS

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(S)-(+)-1-Amino-2-propanol Usage And Synthesis

Chemical Properties

colorless to light yellow liquid

Uses

Emulsifying agent, drycleaning soaps, soluble textile oils, wax removers, metal-cutting oils, cosmetics, emulsion paints, plasticizers, insecticides.

Uses

(S)-(+)-1-Amino-2-propanol may be used in the preparation of S-(+)-1-(2,3-naphthalimido)-2-propanol.

General Description

(S)-(+)-1-Amino-2-propanol is a chiral amino alcohol.

Synthesis

Step (1): dissolve sodium tert-butoxide (230g, 2.39mol) in tetrahydrofuran (2L), slowly add trifluoroacetamide (226g, 2mol) under the ice bath, stirring for 30min; then add S-epoxypropane (128g, 2.2mol) under the ice bath, naturally warmed to room temperature, and continue to stir the reaction for 10h, and then stirred the reaction for another 2h at 35??; after the reaction After the reaction, 2N (equivalent concentration) of hydrochloric acid was added dropwise to the system for neutralization, and then 1L of water was added, static layering, the aqueous phase was extracted with dichloromethane, the organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under pressure to obtain a total of 318g of intermediate product I, with a yield of 93%. Step (2): dissolve the intermediate product I (310g, 1 .81mol) obtained in step (1) in methanol (1 .5L), add 200mL of water and potassium carbonate (550g, 4mol), stirring at room temperature for 6h, filtration, concentration to dryness, the product obtained was dissolved in dichloromethane, filtration, insoluble matter was removed, anhydrous sodium sulfate was dried, concentration, distillation under reduced pressure, the target product S 1-amino-2-propanol totaling 122 g in 90% yield.

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