23-HYDROXYBETULINIC ACID Chemical Properties

Melting point:

>293°C (dec.)

Boiling point:

585.8±25.0 °C(Predicted)

Density 

1.106

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Methanol (Slightly, Heated), Pyridine (Slightly)

form 

Solid

pka

4.60±0.70(Predicted)

color 

White

23-HYDROXYBETULINIC ACID Usage And Synthesis

Description

23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity. It inhibits proliferation of K562, B16, and HeLa cells (IC₅₀s = 39.9, 78.5, and 80 μM, respectively), as well as human umbilical vein endothelial cells (HUVECs; IC₅₀ = 94.8 μM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels.

Uses

23-Hydroxybetulinic Acid is a potential cytoxic agent in the treatment of cancer. Apoptotic effect. Antiproliferative.

Definition

ChEBI: 23-Hydroxybetulinic acid is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane.

23-HYDROXYBETULINIC ACID(85999-40-2)Related Product Information

• Ethylparaben
• Betulinicaldehyde
• Pachymic acid
• Poricoic acid A(F)
• Madecassoside
• Terrestrosin D
• Betulinic acid
• 3-Oxo-olean-12-en-28-oic acid
• Ursonic acid
• Terrestrosin K
• Betulin
• dipotassium dihydrogen 15alpha-hydroxy-2beta-[[2-O-isovaleryl-3,4-di-O-sulphonato-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioate
• roburic acid
• Epibetulinic acid
• Carboxyatractyloside
• Madecassic acid
• ALLEOSIDE A
• Calcium hydroxyphosphate