MANNAN
MANNAN Basic information
- Product Name:
- MANNAN
- Synonyms:
-
- K-41K1
- MANNAN, YEAST
- MANNAN
- mannan from saccharomyces cerevisiae
- MANNAN FROM SACCHAROMYCES CEREVESIAE
- D-Mannan
- Tmac Mannan
- NSC 307194
- CAS:
- 9036-88-8
- MW:
- 0
- Product Categories:
-
- Sugars, Carbohydrates & Glucosides
- Carbohydrates
- Carbohydrates A to
- Carbohydrates M-OBiochemicals and Reagents
- Monosaccharide
- Polysaccharide
- Mol File:
- Mol File
MANNAN Chemical Properties
- refractive index
- 78.5 ° (C=1.4, H2O)
- storage temp.
- 2-8°C
- form
- powder
- color
- Off-white to light yellow
- biological source
- Saccharomyces cerevisiae
- optical activity
- [α]25/D 73 to 82 °, c =1% (w/v) in water
- Water Solubility
- water: ~50g/L
- Merck
- 5744
- CAS DataBase Reference
- 9036-88-8
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-26-36-24/25
- WGK Germany
- 3
- RTECS
- OP1949500
MSDS
- Language:English Provider:SigmaAldrich
MANNAN Usage And Synthesis
Uses
Mannan from Saccharomyces cerevisiae has been used in a study to assess nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages. It has also been used in a study to investigate new lectins from bulbs of Croccus sativum.
General Description
Mannan from Saccharomyces cerevisiae is a simple polysaccharide.
Biological Activity
Mannan exhibits several biological properties, including antiproliferative, antioxidant, and immunomodulatory. It is used as a hardener ingredient and as an emulsion stabilizer. Mannan is also involved in the inhibition of pathogen adherence, regulation of bacterial growth, and enhancement of the immune response.
in vivo
Mannan (50-500 ppm; p.o., dietary; daily; 4 weeks) reduces Aflatoxin B1 (HY-N6615)-induced toxicity in mice, as evidenced by increased body weight, decreased rate of normochromatic erythrocytes with micronuclei, and decreased rate of sister chromatid exchanges[2].
Mannan (50-100 mg/kg; i.p.; 2-5 times) reduces serum levels of low-density lipoprotein (LDL), cholesterol, and triglycerides in mice with acute dyslipidemia induced by poloxamer 407 (HY-D1005)[4].
| Animal Model: | Male CBA/Lac mice (2.5-3-month-old, weighing 22-25 g), acute lipemia induced by poloxamer 407 model[4] |
| Dosage: | 50 mg/kg, 100 mg/kg |
| Administration: | Intraperitoneal injection, 5 times at 50 mg/kg every other day or 2 times at 100 mg/kg with 1-day interval |
| Result: | Reduced the levels of triglyceride, atherogenic LDL, and total cholesterol in the serum at 50 mg/kg and 100 mg/kg. Decreased the triglyceride concentration in the liver. Increased the lability of lysosomal membranes in the liver and elevated the serum activity of chitotriosidase, a marker of macrophage activation. |
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