Pentafluorobenzyl chloride Chemical Properties

Boiling point:

72 °C

Density 

1.59

refractive index 

1.443

Flash point:

72°C/22mm

form 

liquid

Specific Gravity

1.59

color 

Clear, colourless

Water Solubility 

Not miscible in water.

Sensitive 

Lachrymatory

BRN 

647807

CAS DataBase Reference

653-35-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, (chloromethyl)pentafluoro-(653-35-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

2927

Hazard Note 

Irritant/Lachrymatory

HazardClass 

6.1

PackingGroup 

II

HS Code 

2903998090

MSDS

• Language:English Provider:2,3,4,5,6-Pentafluorobenzyl chloride
• Language:English Provider:ALFA

Pentafluorobenzyl chloride Usage And Synthesis

Uses

2,3,4,5,6-Pentafluorobenzyl chloride can be used as a pharmaceutical synthesis intermediate. It can be prepared by reacting hexafluorobenzene with methyllithium and can be used to prepare 2,3,4,5,6-pentafluorobenzyl cyanide.

Synthesis

An ether solution of methyl lithium (70 cc, containing 21 g of methyl lithium) was added to hexafluorobenzene (20 g) in dry ether (20 cc) at a rate sufficient to maintain mild reflux, stirred, and after addition and addition of water (100 cc), stirring was maintained for one hour. The ether layer was dried (MgSO4), filtered, and most of the ether was distilled off through a 6-inch column to separate the residual liquid (17 g), which was passed through a gas chromatograph 100 (column 488 cm x 75 mm, packed with silicone rubber/ diatomaceous earth 1:3, temperature 1000°C, no flow rate 451/hr) to give 2,3,4,5,6-pentafluorotoluene (138 g). Reaction with one molecular equivalent of sulfonyl chloride then halogenates the methyl in the presence of 0005 molecular equivalents of dibenzoyl peroxide The major product is 2,3,4,5,6-pentafluorobenzyl chloride with a boiling point of 88-90°C and a mercury pressure of 69 mm.

Pentafluorobenzyl chloride(653-35-0)Related Product Information

• 2-Chloro-5-chloromethylpyridine
• Choline chloride
• Acetyl chloride
• Cyhalothrin
• Polyvinyl chloride
• Chloromethane
• Calcium chloride
• Benzyl chloride
• Flucloxacillin sodium
• Pivaloyl chloride
• 2-Methylbenzyl chloride
• Sodium chloride
• Benzyl chloromethyl ether
• Pentafluorobenzoyl chloride
• Chloromethyltrimethylsilane
• λ-Cyhalothrin
• tert-Butyldimethylsilyl chloride
• Ammonium chloride