Tylosin phosphate Chemical Properties

Melting point:

>128°C (dec.)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow

Stability:

Hygroscopic

InChIKey

NBOODGNJLRRJNA-DRHKFUGVNA-N

CAS DataBase Reference

1405-53-4(CAS DataBase Reference)

Safety Information

WGK Germany 

2

RTECS 

YP0625000

Toxicity

Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.

Tylosin phosphate Usage And Synthesis

Chemical Properties

Tylosin phosphate (TS) is a light yellow to yellow liquid substance with a characteristic odor.

Tylosin phosphate has an antibacterial effect mainly on Gram-positive bacteria and partly on Gramnegative bacteria and mycoplasma, and has a growth-promoting effect on pigs.

Uses

Tylosin phosphate is a pure-grade antibiotic that was designated as a feed additive as of July 24, 1976. It is used for prevention and control of chronic respiratory disease (CRD) in replacement pullets, broilers, increasing bodyweight and improvement of feed conversion rate in broilers, increasing egg production.

General Description

Tylosin phosphate is an antibacterial agent employed against mycoplasma organisms. It is only used in veterinary field and effective basically against gram positive bacteria, but also has efficacy against some spirochetes and gram negatives (except coliforms). Tylosin phosphate, marketed as Tylan 40 or Tylan 100 Type A medicated article, is approved for use in beef cattle to reduce the incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.

Mechanism of action

Tylosin phosphate is an antibiotic of macrolide group which is produced by fermentation of a certain fungus. This antibiotic prevents protein synthesis by ribosomes and thus prevents bacterial growth, resulting in their death. Special mechanism of action of macrolides, besides stopping rapid growth of microorganisms prevents buildup of bacterial resistance.

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