GALAXOLIDE Chemical Properties

Melting point:

57-58°

Boiling point:

304 °C(lit.)

Density 

1.044 g/mL at 25 °C(lit.)

vapor pressure 

0.073Pa at 25℃

refractive index 

n20/D 1.5215(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

Odor

at 100.00 %. strong diffusive sweet floral musk

Odor Type

musk

Water Solubility 

1.65mg/L at 25℃

LogP

5.3 at 25℃

CAS DataBase Reference

1222-05-5(CAS DataBase Reference)

EPA Substance Registry System

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (1222-05-5)

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

38-50/53

Safety Statements 

26-36-61

RIDADR 

UN 3082 9 / PGIII

WGK Germany 

3

HS Code 

2932.99.7000

HazardClass 

9

PackingGroup 

III

Hazardous Substances Data

1222-05-5(Hazardous Substances Data)

Toxicity

LD50 skin in rat: > 5gm/kg

MSDS

• Language:English Provider:SigmaAldrich

GALAXOLIDE Usage And Synthesis

Chemical Properties

Clear Colourless to Pale Yellow Oil

Chemical Properties

4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with a musk-like odor. It is one of the most frequently used synthetic, artificial musk fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane, which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts reaction using aluminum chloride as a catalyst (analogous to the synthesis of phenylethyl alcohol from benzene and ethylene oxide . Ring closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane is accomplished with paraformaldehyde and a lower aliphatic alcohol via the acetal or with paraformaldehyde and a carboxylic acid anhydride via the acylate.
The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not discolor in light. Therefore, it is a popular ingredient of perfume compositions for soaps, detergents, and cosmetics and is used in large amounts.

Uses

Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.

Definition

ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.

General Description

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran is an isochromone with a strong musk odor, commonly used in fragrances.

Flammability and Explosibility

Not classified

Trade name

Galaxolide® (IFF), Astromusk (Agan),Musk YingHai (YingHai).

GALAXOLIDE(1222-05-5)Related Product Information

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