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GALAXOLIDE

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GALAXOLIDE Basic information

Product Name:
GALAXOLIDE
Synonyms:
  • ABBALIDE
  • 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA[G]-2-BENZOPYRAN
  • 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL-CYCLOPENTA-GAMMA-2-BENZOPYRAN
  • 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta(g)-2-benzopyra
  • GALAXOLIDE
  • GALAXOLIDE 50
  • GALAXOLIDE 50 BB
  • GALAXOLIDE 50 IPM
CAS:
1222-05-5
MF:
C18H26O
MW:
258.4
EINECS:
214-946-9
Product Categories:
  • Aromatics
  • Detergents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Alphabetical Listings
  • Flavors and Fragrances
  • G-H
Mol File:
1222-05-5.mol
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GALAXOLIDE Chemical Properties

Melting point:
57-58°
Boiling point:
304 °C(lit.)
Density 
1.044 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5215(lit.)
Flash point:
>230 °F
CAS DataBase Reference
1222-05-5(CAS DataBase Reference)
EPA Substance Registry System
1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (1222-05-5)
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Safety Information

Hazard Codes 
Xi,N
Risk Statements 
38-50/53
Safety Statements 
26-36-61
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
3
HazardClass 
9
PackingGroup 
III
Toxicity
LD50 skin in rat: > 5gm/kg

MSDS

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GALAXOLIDE Usage And Synthesis

Chemical Properties

Clear Colourless to Pale Yellow Oil

Chemical Properties

4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with a musk-like odor. It is one of the most frequently used synthetic, artificial musk fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane, which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts reaction using aluminum chloride as a catalyst (analogous to the synthesis of phenylethyl alcohol from benzene and ethylene oxide . Ring closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane is accomplished with paraformaldehyde and a lower aliphatic alcohol via the acetal or with paraformaldehyde and a carboxylic acid anhydride via the acylate.
The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not discolor in light. Therefore, it is a popular ingredient of perfume compositions for soaps, detergents, and cosmetics and is used in large amounts.

Uses

Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.

Definition

ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.

Trade name

Galaxolide® (IFF), Astromusk (Agan),Musk YingHai (YingHai).

GALAXOLIDESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Email
Sales-CN@TCIchemicals.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ;021-54308259-
Email
info@hanhonggroup.com;info@hanhonggroup.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915- ;021-51613915-822
Email
latika.cui@3wpharm.com;vivian.zhu@3wpharm.com