Tetrahydropyran Chemical Properties

Melting point:

-45 °C (lit.)

Boiling point:

88 °C (lit.)

Density 

0.881 g/mL at 25 °C (lit.)

vapor density 

3 (vs air)

refractive index 

n20/D 1.42(lit.)

Flash point:

4 °F

storage temp. 

Store below +30°C.

solubility 

>80.2g/l

form 

Liquid

color 

Clear colorless

Odor

at 0.10?%?in?dipropylene glycol. pungent sweet ethereal

Water Solubility 

80 g/L (25 ºC)

Merck 

14,9217

BRN 

102436

Dielectric constant

7.3（30℃）

InChIKey

DHXVGJBLRPWPCS-UHFFFAOYSA-N

LogP

0.950

CAS DataBase Reference

142-68-7(CAS DataBase Reference)

NIST Chemistry Reference

2H-Pyran, tetrahydro-(142-68-7)

EPA Substance Registry System

Tetrahydropyran (142-68-7)

Safety Information

Hazard Codes 

F,Xi,Xn

Risk Statements 

11-36/37/38-9-19-52/53-22

Safety Statements 

9-16-26-33-36-61

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29321100

Hazardous Substances Data

142-68-7(Hazardous Substances Data)

MSDS

• Language:English Provider:Pentamethylene oxide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tetrahydropyran Usage And Synthesis

Description

Tetrahydropyran (THP) is the organic compound consisting of a saturated six-membered ring containing five carbon atoms and one oxygen atom. It is named by reference to pyran, which contains two double bonds, and may be produced from it by adding four hydrogens. Tetrahydropyran can be used as a solvent in various classical organic reactions such as radical reactions, palladium-catalyzed coupling, and Grignard reactions.

Chemical Properties

colorless to light yellow liquid

Uses

It is is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. They are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization.

Definition

ChEBI: A saturated organic heteromonocyclic parent that is cyclohexane in which one of the carbon atoms has been replaced by an oxygen atom.

Purification Methods

Dry oxane with CaH2, then pass it through a column of silica gel to remove olefinic impurities and fractionally distil it. Free it from peroxides and moisture by refluxing with sodium, then distil it from LiAlH4. Alternatively, peroxides can be removed by treatment with aqueous ferrous sulfate and sodium bisulfate, followed by solid KOH, and fractional distillation from sodium. [Beilstein 17 H 12, 17 I 6, 17 II 18, 17 III/IV 51, 17/1 V 64.]

Tetrahydropyran(142-68-7)Related Product Information

• Propylene oxide
• Tetramethylammonium hydroxide
• Tetrahydro-2H-pyran-4-carboxylic acid
• 4-Aminotetrahydropyran
• NITRIC OXIDE
• ETHYLENE OXIDE
• Tetrahydro-4H-pyran-4-one
• Iron oxide
• Tetrahydrofuran
• Magnesium oxide
• cis-1,2,3,6-Tetrahydrophthalic anhydride
• Zinc oxide
• Cuprous oxide
• Methyl tetrahydropyran-4-carboxylate
• Pyrrolidine
• (Diethoxymethyl)diphenylphosphine oxide
• Tetrahydro-2H-pyran-4-carbonyl chloride
• Tetrahydro-4-pyranol