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6-HYDROXYFLAVANONE

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6-HYDROXYFLAVANONE Basic information

Product Name:
6-HYDROXYFLAVANONE
Synonyms:
  • HYDROXYFLAVANONE, 6-
  • 6'-HYDROXYFLAVANONE
  • 6-HYDROXYFLAVANONE
  • 2-Phenyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one
  • 6-OH Flavanone
  • 6-hydroxy-2-phenylchroMan-4-one
  • 6-Hydroxyflavanone 99%
  • 6-Hydroxyflavanone,98+%
CAS:
4250-77-5
MF:
C15H12O3
MW:
240.25
EINECS:
624-472-8
Product Categories:
  • Flavanones
  • Biochemistry
  • Flavonoids
  • Benzopyrans
  • Building Blocks
  • Heterocyclic Building Blocks
Mol File:
4250-77-5.mol
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6-HYDROXYFLAVANONE Chemical Properties

Melting point:
220-222 °C (dec.) (lit.)
Boiling point:
464.3±45.0 °C(Predicted)
Density 
1.288±0.06 g/cm3(Predicted)
pka
9.53±0.40(Predicted)
form 
powder to crystal
color 
White to Orange to Green
BRN 
87354
LogP
2.955 (est)
CAS DataBase Reference
4250-77-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29329900

MSDS

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6-HYDROXYFLAVANONE Usage And Synthesis

Chemical Properties

Slightly yellow-cream powder

Uses

6-Hydroxyflavanone (6-HF) has been used for the enantiomeric separation of flavonoids using polysaccharide-based chiral stationary phases by nano-liquid chromatography (nano-LC). Racemic 6-HF may be used in the synthesis of 6-propionoxy-flavanone (6-PF). 6-HF may be employed as synthetic flavone to investigate the mechanism of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced cytotoxic and apoptotic effects in HeLa cancer cells.

Definition

ChEBI: A monohydroxyflavanone that is flavanone substituted by a hydroxy group at position 6.

General Description

6-Hydroxyflavanone is a flavonoid. Its biotransformation by Aspergillus niger strains have been described. Crystal structure of S and R enanti-omers of 6-hydroxyflavanone has been reported to have four crystallographic sites of the unit cell in an approximate 3:1/1:3 ratio. It was identified as a metabolite of flavnone on incubation with rat liver microsomes by positive ion electrospray LC/MS analysis.

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