Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  fatty acid >  1,3-Acetonedicarboxylic acid

1,3-Acetonedicarboxylic acid

Basic information Safety Supplier Related

1,3-Acetonedicarboxylic acid Basic information

Product Name:
1,3-Acetonedicarboxylic acid
Synonyms:
  • 1,3-Acetonedicarboxylic acid,96%
  • 1,3-Acetonediacrboxylicacid
  • 3-oxo-pentanedioicaci
  • 3-Oxopentane-1,5-dioic acid
  • 1,3-ACETONEDICARBOXYLIC ACID, TECH.
  • 1,3-ACETONEDICARBOXYLIC ACID, 3-KETOGLUTARIC ACID
  • Acetone-1,3-dicarboxylicacid,97%
  • 2-OXO-1,3-PROPANE DICARBOXYLIC ACID
CAS:
542-05-2
MF:
C5H6O5
MW:
146.1
EINECS:
208-797-9
Product Categories:
  • Pharmaceutical Intermediates
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • API intermediates
  • Pharmaceutical raw materials
  • pharmaceutical
  • bc0001
  • 542-05-2
Mol File:
542-05-2.mol
More
Less

1,3-Acetonedicarboxylic acid Chemical Properties

Melting point:
133 °C (dec.) (lit.)
Boiling point:
185.67°C (rough estimate)
Density 
1.2821 (rough estimate)
vapor pressure 
0.005Pa at 25℃
refractive index 
1.3920 (estimate)
storage temp. 
-20°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
pka
pK (25°) 3.10
form 
Crystalline Powder
color 
White
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,68
BRN 
1447081
Stability:
Unstable in Solution
InChIKey
OXTNCQMOKLOUAM-UHFFFAOYSA-N
LogP
-0.5 at 30℃
CAS DataBase Reference
542-05-2(CAS DataBase Reference)
EPA Substance Registry System
Pentanedioic acid, 3-oxo- (542-05-2)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
44-36/37/38
Safety Statements 
22-24/25-37/39-26-36
WGK Germany 
3
3
TSCA 
Yes
HS Code 
29183000

MSDS

More
Less

1,3-Acetonedicarboxylic acid Usage And Synthesis

Chemical Properties

white to off-white powder

Physical properties

Acetonedicarboxylic acid forms colorless crystals that are readily soluble in water and ethanol, and sparingly soluble in trichloromethane and diethyl ether. It melts with decomposition at 138 ℃.

Uses

β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.

Uses

Acetone-1,3-dicarboxylic acid is used as a building block in organic chemistry. It is also used in the synthesis of hetrocyclic rings and in the Weiss-Cook reaction, which involves the preparation of cis-bicyclo[3.3.0]octane-3,7-dione by reacting with diacyl (1,2 ketone). Its presence in human urine is used as a diagnostic test for the overgrowth of harmful gut flora such as Candida albicans.

Definition

ChEBI: 3-Oxoglutaric acid is an oxo carboxylic acid.

Production Methods

Acetonedicarboxylic acid is produced from citric acid [77-92-9] by many industrial processes that differ only slightly. Citric acid is treated with oleum and reacts to yield acetonedicarboxylic acid via decarbonylation and dehydration.
Other possible production methods include reaction of acetone with carbon dioxide, oxidation of citric acid with chlorosulfuric acid, or reaction of ketene with phosgene.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from ethyl acetate and store it over P2O5. It decarboxylates in hot water. [Beilstein 3 IV 1816.]

1,3-Acetonedicarboxylic acidSupplier

Shanxi jiaernuo Biotechnology Co.,LTD. Gold
Tel
0913-2034526; 13992350171
Email
540492555@qq.com
Weinan Ruilin Changxin Biotechnology Co., Ltd Gold
Tel
13892558122 13892558122; 13892558122
Email
1550396525@qq.com
Jinan Yuantai Pharmaceutical Co.,Ltd Gold
Tel
0531-69959492 15966603228
Email
85633700@qq.com
Cool Pharm, Ltd Gold
Tel
18019463053
Email
sales@coolpharm.com
Weinan Ruilin Changxin Biotechnology Co., Ltd Gold
Tel
13892558122 13892558122 13892558122
Email
1550396525@qq.com