1,3-Acetonedicarboxylic acid
1,3-Acetonedicarboxylic acid Basic information
- Product Name:
- 1,3-Acetonedicarboxylic acid
- Synonyms:
-
- 1,3-Acetonedicarboxylic acid,96%
- 1,3-Acetonediacrboxylicacid
- 3-oxo-pentanedioicaci
- 3-Oxopentane-1,5-dioic acid
- 1,3-ACETONEDICARBOXYLIC ACID, TECH.
- 1,3-ACETONEDICARBOXYLIC ACID, 3-KETOGLUTARIC ACID
- Acetone-1,3-dicarboxylicacid,97%
- 2-OXO-1,3-PROPANE DICARBOXYLIC ACID
- CAS:
- 542-05-2
- MF:
- C5H6O5
- MW:
- 146.1
- EINECS:
- 208-797-9
- Product Categories:
-
- Pharmaceutical Intermediates
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- API intermediates
- Pharmaceutical raw materials
- pharmaceutical
- bc0001
- 542-05-2
- Mol File:
- 542-05-2.mol
1,3-Acetonedicarboxylic acid Chemical Properties
- Melting point:
- 133 °C (dec.) (lit.)
- Boiling point:
- 185.67°C (rough estimate)
- Density
- 1.2821 (rough estimate)
- vapor pressure
- 0.005Pa at 25℃
- refractive index
- 1.3920 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- pK (25°) 3.10
- form
- Crystalline Powder
- color
- White
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- Merck
- 14,68
- BRN
- 1447081
- Stability:
- Unstable in Solution
- InChIKey
- OXTNCQMOKLOUAM-UHFFFAOYSA-N
- LogP
- -0.5 at 30℃
- CAS DataBase Reference
- 542-05-2(CAS DataBase Reference)
- EPA Substance Registry System
- Pentanedioic acid, 3-oxo- (542-05-2)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 44-36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- F
- 3
- TSCA
- Yes
- HS Code
- 29183000
MSDS
- Language:English Provider:3-Oxoglutaric acid
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
1,3-Acetonedicarboxylic acid Usage And Synthesis
Chemical Properties
white to off-white powder
Physical properties
Acetonedicarboxylic acid forms colorless crystals that are readily soluble in water and ethanol, and sparingly soluble in trichloromethane and diethyl ether. It melts with decomposition at 138 ℃.
Uses
β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.
Uses
Acetone-1,3-dicarboxylic acid is used as a building block in organic chemistry. It is also used in the synthesis of hetrocyclic rings and in the Weiss-Cook reaction, which involves the preparation of cis-bicyclo[3.3.0]octane-3,7-dione by reacting with diacyl (1,2 ketone). Its presence in human urine is used as a diagnostic test for the overgrowth of harmful gut flora such as Candida albicans.
Definition
ChEBI: 3-Oxoglutaric acid is an oxo carboxylic acid.
Production Methods
Acetonedicarboxylic acid is
produced from citric acid [77-92-9] by many
industrial processes that differ only slightly. Citric acid is treated with oleum and
reacts to yield acetonedicarboxylic acid via decarbonylation and dehydration.
Other possible production methods include
reaction of acetone with carbon dioxide, oxidation of citric acid with chlorosulfuric
acid, or reaction of ketene with phosgene.
Flammability and Explosibility
Non flammable
Purification Methods
Crystallise it from ethyl acetate and store it over P2O5. It decarboxylates in hot water. [Beilstein 3 IV 1816.]
1,3-Acetonedicarboxylic acid Preparation Products And Raw materials
Preparation Products
Raw materials
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1,3-Acetonedicarboxylic acid(542-05-2)Related Product Information
- Ethyl 2-(Chlorosulfonyl)acetate
- Diacetone Alcohol
- 1,3-Dihydroxyacetone
- Hyaluronic acid
- Citric acid
- Dibenzylideneacetone
- 2,5-PYRIDINEDICARBOXYLIC ACID
- Folic acid
- Diethyl ketomalonate
- 2,2-Dipropylmalonic acid
- Diethyl propylmalonate
- Ascoric Acid
- Phenylacetone
- Propiophenone
- Diethyl-1,3-acetonedicarboxylic acid,1,3-ACETONEDICARBOXYLIC ACID DIETHYL ESTER,ACETONEDICARBOXYLIC ACID DIETHYL ESTER,Acetonedicarboxylic acid diethylether
- 3,3'-CARBONYLBIS(7-DIETHYLAMINOCOUMARIN)
- 3,3'-CARBONYLBIS(7-METHOXYCOUMARIN)
- 1,3-Acetonedicarboxylic acid anhydride,1,3-ACETONEDICARBOXYLIC ACID ANHYDRIDE 98,1,3-Acetonedicarboxylic acid anhydride 98%