4-Fluoronitrobenzene Chemical Properties

Melting point:

21 °C (lit.)

Boiling point:

205 °C (lit.)

Density 

1.33 g/mL at 25 °C (lit.)

vapor density 

>1 (vs air)

vapor pressure 

5.5 mm Hg ( 70 °C)

refractive index 

n20/D 1.531(lit.)

Flash point:

182 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid After Melting

Specific Gravity

1.330

color 

deep greenish-yellow

Water Solubility 

Insoluble in water.

BRN 

606923

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

InChIKey

WFQDTOYDVUWQMS-UHFFFAOYSA-N

LogP

1.8 at 20℃

CAS DataBase Reference

350-46-9(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-fluoro-4-nitro-(350-46-9)

EPA Substance Registry System

p-Fluoronitrobenzene (350-46-9)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

20/21/22-33

Safety Statements 

36-36/37

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

1

RTECS 

DA1400000

Hazard Note 

Toxic/Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29049085

Hazardous Substances Data

350-46-9(Hazardous Substances Data)

MSDS

• Language:English Provider:p-Fluoronitrobenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Fluoronitrobenzene Usage And Synthesis

Uses

4-Nitrofluorobenzene, is an aryl fluorinated building block, and a common intermediate used for the synthesis of many industrial useful compounds. It is used for the preparation of novel soluble aromatic polyimides, such as 1,3,5-Tris(4-aminophenoxy)benzene (TAB).

Chemical Properties

yellow liquid

Uses

1-Fluoro-4-nitrobenzene used as a component of hair dyes, as pharmaceutical intermediates. It is also used for the preparation of novel soluble aromatic polyimides

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 6034, 1956 DOI: 10.1021/ja01604a022
Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Tetrahedron Letters, 30, p. 7199, 1989 DOI: 10.1016/S0040-4039(01)93933-4

Flammability and Explosibility

Non flammable

Synthesis

Synthesis of 4-fluoronitrobenzene. Reagents and conditions: (a) PCl5 (1.1 equiv.), PhPOCl2 (0.11 equiv.), 160°C, 8 h (<65%); (b) KF (1.5 equiv.), bis(phosphoranylidene)ammonium chloride (0.04  equiv.), DMSO, 150°C, 8 h (51%).

Purification Methods

Crystallise it from EtOH. [Beilstein 5 H 241, 5 IV 719.]

4-Fluoronitrobenzene(350-46-9)Related Product Information

• 4-Nitrobenzoic acid
• 4-Nitrophenyl phosphate bis(cyclohexylammonium) salt
• 3-(4-Nitrophenyl)-beta-alanine
• 4-Nitrobenzaldehyde
• 4-Fluorothiophenol
• 4-Fluorobenzaldehyde
• 4-Fluorophenoxyacetic acid
• Methyl 4-fluorobenzoate
• Ethyl 4-fluorobenzoate
• 4-Fluorobenzoic acid
• 4-Fluorobenzonitrile
• 4-Fluorobenzyl chloride
• 4-Fluorophenylacetic acid
• 4-Bromofluorobenzene
• 3,4-Difluoronitrobenzene
• Nitrobenzene
• 4-Bromo-1-fluoro-2-nitrobenzene
• 1,2,3-Trifluoro-4-nitrobenzene